HitPredict

Interactor 1: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Interactor 2: FBXW7 (Q9VZF4)
F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (Protein archipelago)
Gene: ago

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0060253 - negative regulation of glial cell proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 669 Dm			1 1326
+	Hs
		681967 AKT1_HUMAN (13-360): 6.81e-132: 398: 20.06		FBXW7_HUMAN (1061-1324): 1.93e-77: 273: 37.08
+	Dm
		1249839 HIPPO_DROME (1-669): 0: 542: 100.00		Q9VDE3_DROME (1221-1318): 3.84e-14: 78.7: 22.22
+	Hs
		1272883 M4K1_HUMAN (38-293): 1.26e-69: 244: 44.87		FBXW7_HUMAN (1061-1324): 1.93e-77: 273: 37.08
+	Dm
		90543 E1JGN0_DROME (12-664): 1.2e-129: 412: 16.57		Q9VDE3_DROME (1221-1318): 3.84e-14: 78.7: 22.22
+	Dm
		1213409 AKT1_DROME (23-354): 8.43e-131: 400: 19.01		NLE_DROME (1226-1324): 3.8e-16: 85.2: 16.67
+	Hs
		129064 PLK4_HUMAN (40-641): 1.11e-128: 405: 19.44		FBW1B_HUMAN (1228-1323): 5.1e-14: 78.7: 20.83
+	Hs
		129069 PLK4_HUMAN (40-641): 1.11e-128: 405: 19.44		FBW1A_HUMAN (1228-1318): 8.5e-14: 77.9: 25.28
+	Dm
		1213390 AKT1_DROME (23-354): 8.43e-131: 400: 19.01		Q9VDE3_DROME (1221-1318): 3.84e-14: 78.7: 22.22
+	Dm
		218248 AKT1_DROME (23-354): 8.43e-131: 400: 19.01		O44382_DROME (1221-1318): 3.84e-14: 78.7: 22.22
+	Hs
		682082 AKT1_HUMAN (13-360): 6.81e-132: 398: 20.06		FBW1A_HUMAN (1228-1318): 8.5e-14: 77.9: 25.28
+	Hs
		568826 KAPCA_HUMAN (6-346): 3.17e-130: 389: 21.94		FBW1B_HUMAN (1228-1323): 5.1e-14: 78.7: 20.83
+	Hs
		568836 KAPCA_HUMAN (6-346): 3.17e-130: 389: 21.94		FBW1A_HUMAN (1228-1318): 8.5e-14: 77.9: 25.28
+	Dm
		1363651 PAK_DROME (17-314): 9.61e-114: 359: 36.89		Q9VDE3_DROME (1221-1318): 3.84e-14: 78.7: 22.22
+	Hs
		793038 TNIK_HUMAN (33-320): 1.39e-62: 228: 41.06		LIS1_HUMAN (726-1063): 3.17e-42: 162: 12.61
+	Hs
		1027412 STK3_HUMAN (502-661): 1.12e-16: 85.2: 24.22		FBXW7_HUMAN (1061-1324): 1.93e-77: 273: 37.08
+	Hs
		1163009 M4K3_HUMAN (38-308): 1.71e-71: 250: 44.25		TRAF7_HUMAN (1107-1317): 1.9e-14: 80.5: 31.02
+	Hs
		1163057 M4K5_HUMAN (34-293): 1.19e-68: 241: 44.57		TRAF7_HUMAN (1107-1317): 1.9e-14: 80.5: 31.02
+	Hs
		1023136 STK4_HUMAN (537-661): 8.11e-18: 88.9: 29.60		FBW1B_HUMAN (1228-1323): 5.1e-14: 78.7: 20.83
+	Hs
		1023143 STK4_HUMAN (537-661): 8.11e-18: 88.9: 29.60		FBW1A_HUMAN (1228-1318): 8.5e-14: 77.9: 25.28
+	Hs
		1027451 STK3_HUMAN (502-661): 1.12e-16: 85.2: 24.22		FBW1B_HUMAN (1228-1323): 5.1e-14: 78.7: 20.83