Protein: IF4G3
Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII)

Gene: IF4G3, EIF4G3
Organism: Homo sapiens
Interactions: 114
UniProt ID: O43432

Gene Ontology (top 5):
GO:0000339 - RNA cap binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

216071

IF4A1
Eukaryotic initiation factor 4A-I

8

20

Small-scale

0.967

High

216077

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

6

9

High-throughput

0.931

High

216087

IF4A2
Eukaryotic initiation factor 4A-II

3

20

High-throughput

0.839

High

216046

IF4E
Eukaryotic translation initiation factor 4E

9

18

Small-scale

0.754

High

211237

RFOX2
RNA binding protein fox-1 homolog 2

3

11

High-throughput

0.667

High

216090

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.667

High

216069

EIF3B
Eukaryotic translation initiation factor 3 subunit B

3

13

Small-scale

0.656

High

216042

ESR1
Estrogen receptor

3

14

High-throughput

0.640

High

216049

PABP1
Polyadenylate-binding protein 1

2

15

Small-scale

0.634

High

216114

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.628

High

216056

DDX6
Probable ATP-dependent RNA helicase DDX6

1

14

High-throughput

0.618

High

216079

NCBP1
Nuclear cap-binding protein subunit 1

1

4

Small-scale

0.618

High

216088

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

8

Small-scale

0.611

High

216100

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

2

High-throughput

0.609

High

216116

TET5A
Terminal nucleotidyltransferase 5A

2

0

High-throughput

0.602

High

216132

HAOX2
2-Hydroxyacid oxidase 2

2

0

High-throughput

0.602

High

131239

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

7

High-throughput

0.584

High

187828

EIF3H
Eukaryotic translation initiation factor 3 subunit H

2

8

High-throughput

0.584

High

216107

NF2IP
NFATC2-interacting protein

2

1

High-throughput

0.574

High

216048

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.571

High

216038

PCNT
Pericentrin

1

5

High-throughput

0.541

High

216045

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.541

High

214260

MSI1H
RNA-binding protein Musashi homolog 1

1

15

High-throughput

0.536

High

216034

HTRA2
Serine protease HTRA2, mitochondrial

1

3

High-throughput

0.536

High

216040

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

216050

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

4

High-throughput

0.536

High

216055

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

216058

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.536

High

216059

RL4
Large ribosomal subunit protein uL4

1

3

High-throughput

0.536

High

216061

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.536

High

216062

PRS6B
26S proteasome regulatory subunit 6B

1

2

High-throughput

0.536

High

216072

1433G
14-3-3 protein gamma

1

9

High-throughput

0.536

High

216078

1433F
14-3-3 protein eta

1

8

High-throughput

0.536

High

216109

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

216126

SHRPN
Sharpin

1

1

High-throughput

0.536

High

216137

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.536

High

216074

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

216112

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

216066

VAV2
Guanine nucleotide exchange factor VAV2

1

5

High-throughput

0.508

High

216124

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

5

High-throughput

0.508

High

216047

YES
Tyrosine-protein kinase Yes

1

1

High-throughput

0.501

High

216075

EFNB1
Ephrin-B1

1

2

High-throughput

0.489

High

216092

CTR9
RNA polymerase-associated protein CTR9 homolog

1

7

High-throughput

0.489

High

216094

BTNL9
Butyrophilin-like protein 9

1

1

High-throughput

0.489

High

216101

VRK2
Serine/threonine-protein kinase VRK2

1

1

High-throughput

0.489

High

216102

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

1

High-throughput

0.489

High

216117

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

216118

TGM7
Protein-glutamine gamma-glutamyltransferase Z

1

2

High-throughput

0.489

High

216119

TCPQM
T-complex protein 1 subunit theta-like 2

1

2

High-throughput

0.489

High

216120

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

187595

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

216036

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

216037

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

20

High-throughput

0.479

High

216039

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

216041

RASK
GTPase KRas

1

8

High-throughput

0.479

High

216051

EZRI
Ezrin

1

3

High-throughput

0.479

High

216052

PRS6A
26S proteasome regulatory subunit 6A

1

8

High-throughput

0.479

High

216057

HS71L
Heat shock 70 kDa protein 1-like

1

4

High-throughput

0.479

High

216060

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

216063

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

216065

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

2

High-throughput

0.479

High

216067

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

216070

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.479

High

216073

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

216076

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

216080

TADBP
TAR DNA-binding protein 43

1

16

High-throughput

0.479

High

216081

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

216082

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.479

High

216083

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

4

High-throughput

0.479

High

216084

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

4

High-throughput

0.479

High

216085

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.479

High

216086

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

10

High-throughput

0.479

High

216089

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

216097

RS27L
Ribosomal protein eS27-like

1

2

High-throughput

0.479

High

216098

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.479

High

216099

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

216108

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

216110

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

216113

DAZL
Deleted in azoospermia-like

1

14

High-throughput

0.479

High

216121

NECD
Necdin

1

5

High-throughput

0.479

High

216122

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.479

High

216123

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

5

High-throughput

0.479

High

216128

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

216133

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

2

High-throughput

0.479

High

216136

ANGE1
Protein angel homolog 1

1

1

High-throughput

0.479

High

216138

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

3

High-throughput

0.479

High

216140

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

216068

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

216130

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

171364

S27A2
Long-chain fatty acid transport protein 2

1

4

High-throughput

0.445

High

216095

NBEL2
Neurobeachin-like protein 2

1

6

High-throughput

0.445

High

216139

WDR37
WD repeat-containing protein 37

1

9

Small-scale

0.439

High

216035

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

216043

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.437

High

216044

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

216054

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.437

High

216093

LMBRL
Protein LMBR1L

1

4

High-throughput

0.437

High

216096

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

216106

ARL10
ADP-ribosylation factor-like protein 10

1

4

High-throughput

0.437

High

216111

ESR2
Estrogen receptor beta

1

13

High-throughput

0.437

High

216125

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.437

High

216127

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

216129

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

216134

XPO7
Exportin-7

1

8

High-throughput

0.437

High

216135

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

High-throughput

0.437

High

216103

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

216141

KPTN
KICSTOR complex protein kaptin

3

0

High-throughput

0.347

High

216053

EPHA1
Ephrin type-A receptor 1

2

0

High-throughput

0.328

High

216105

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

216104

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.318

High

216091

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

0

High-throughput

0.279

Low

216115

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

216131

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

216064

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025