HitPredict - High confidence protein-protein interactions

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	17996703, 17719543, 26949039, 19997087, 27295432, 28475870, 30207403, 31048545, 31578285, 36773333, 36897111, 22496338, 23938591, 21258410
Identification Methods	enzymatic study, pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HECT~HECT, HECT~WW, WW~WW
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000151 - ubiquitin ligase complex GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm and 24 others more... GO:0005829 - cytosol GO:0006366 - transcription by RNA polymerase II GO:0006858 - extracellular transport GO:0008134 - transcription factor binding GO:0010629 - negative regulation of gene expression GO:0016020 - membrane GO:0016567 - protein ubiquitination GO:0032410 - negative regulation of transporter activity GO:0034765 - regulation of monoatomic ion transmembrane transport GO:0036211 - protein modification process GO:0042391 - regulation of membrane potential GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043433 - negative regulation of DNA-binding transcription factor activity GO:0045746 - negative regulation of Notch signaling pathway GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046718 - symbiont entry into host cell GO:0051224 - negative regulation of protein transport GO:0051865 - protein autoubiquitination GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0061630 - ubiquitin protein ligase activity GO:0070062 - extracellular exosome GO:0070534 - protein K63-linked ubiquitination GO:1901016 - regulation of potassium ion transmembrane transporter activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1	870
Hs

1	870

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Last updated: 15 Jul 2024