Protein: GTPB1
GTP-binding protein 1 (G-protein 1) (GP-1) (GP1)

Gene: GTPB1, GTPBP1
Organism: Homo sapiens
Interactions: 120
UniProt ID: O00178

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003746 - translation elongation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

124885

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

10

High-throughput

0.667

High

124904

VASP
Vasodilator-stimulated phosphoprotein

3

2

High-throughput

0.667

High

124963

RAB17
Ras-related protein Rab-17

3

3

High-throughput

0.667

High

124980

COR1C
Coronin-1C

2

5

High-throughput

0.628

High

124949

CSN5
COP9 signalosome complex subunit 5

2

15

High-throughput

0.611

High

124883

A4
Amyloid-beta precursor protein

2

4

High-throughput

0.602

High

124869

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

124875

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

12

High-throughput

0.584

High

124950

ISOC2
Isochorismatase domain-containing protein 2

2

1

High-throughput

0.574

High

124905

RB27A
Ras-related protein Rab-27A

1

3

High-throughput

0.536

High

124907

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

124915

IRF5
Interferon regulatory factor 5

1

2

High-throughput

0.536

High

124916

CUL3
Cullin-3

1

19

High-throughput

0.536

High

124936

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.536

High

124941

MINK1
Misshapen-like kinase 1

1

6

High-throughput

0.536

High

124957

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

124962

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.536

High

124983

KIF3A
Kinesin-like protein KIF3A

1

3

High-throughput

0.536

High

124922

E2F4
Transcription factor E2F4

2

2

High-throughput

0.533

High

124900

CCNF
Cyclin-F

1

6

High-throughput

0.515

High

124919

ABRX2
BRISC complex subunit Abraxas 2

1

0

High-throughput

0.513

High

124954

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

7

High-throughput

0.489

High

124867

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

2

High-throughput

0.479

High

124868

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

124873

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

124874

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

124877

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

124879

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

124882

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

124886

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.479

High

124887

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

124892

DDX6
Probable ATP-dependent RNA helicase DDX6

1

6

High-throughput

0.479

High

124895

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

124896

MERL
Merlin

1

3

High-throughput

0.479

High

124898

ZEB1
Zinc finger E-box-binding homeobox 1

1

4

Small-scale

0.479

High

124899

SYUA
Alpha-synuclein

1

4

High-throughput

0.479

High

124901

SYQ
Glutamine--tRNA ligase

1

6

High-throughput

0.479

High

124906

KS6A3
Ribosomal protein S6 kinase alpha-3

1

7

High-throughput

0.479

High

124909

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

124910

VIGLN
Vigilin

1

13

High-throughput

0.479

High

124911

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.479

High

124912

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

8

High-throughput

0.479

High

124951

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

1

1

High-throughput

0.479

High

124913

FAK1
Focal adhesion kinase 1

1

5

High-throughput

0.479

High

124914

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

124918

PUM1
Pumilio homolog 1

1

8

High-throughput

0.479

High

124920

SYK
Lysine--tRNA ligase

1

14

High-throughput

0.479

High

124924

HABP4
Intracellular hyaluronan-binding protein 4

1

4

High-throughput

0.479

High

124926

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

8

Small-scale

0.479

High

124927

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

124929

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

124931

MEX3B
RNA-binding protein MEX3B

1

2

High-throughput

0.479

High

124934

PATL1
Protein PAT1 homolog 1

1

3

High-throughput

0.479

High

124938

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

124940

NIN
Ninein

1

1

High-throughput

0.479

High

124944

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

124945

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.479

High

124947

DI3L1
DIS3-like exonuclease 1

1

3

High-throughput

0.479

High

124953

FUBP3
Far upstream element-binding protein 3

1

12

High-throughput

0.479

High

124955

SCLT1
Sodium channel and clathrin linker 1

1

2

High-throughput

0.479

High

124960

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

7

High-throughput

0.479

High

124961

TRI31
E3 ubiquitin-protein ligase TRIM31

1

14

High-throughput

0.479

High

124965

VP33B
Vacuolar protein sorting-associated protein 33B

1

2

High-throughput

0.479

High

124967

TDRD3
Tudor domain-containing protein 3

1

2

High-throughput

0.479

High

124968

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

1

High-throughput

0.479

High

124970

MOV10
Helicase MOV-10

1

10

High-throughput

0.479

High

124971

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

124972

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.479

High

124973

ANLN
Anillin

1

2

High-throughput

0.479

High

124974

DIAP3
Protein diaphanous homolog 3

1

3

High-throughput

0.479

High

124975

KTU
Protein kintoun

1

2

High-throughput

0.479

High

124976

SYLC
Leucine--tRNA ligase, cytoplasmic

1

16

High-throughput

0.479

High

124977

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

124978

TNIK
TRAF2 and NCK-interacting protein kinase

1

8

High-throughput

0.479

High

124981

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

124982

R3HD2
R3H domain-containing protein 2

1

2

High-throughput

0.479

High

124985

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

124986

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

13

High-throughput

0.479

High

124948

DUS19
Dual specificity protein phosphatase 19

1

2

High-throughput

0.470

High

124917

UBP2L
Ubiquitin-associated protein 2-like

1

0

High-throughput

0.458

High

124921

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

124923

FSCN1
Fascin

1

0

High-throughput

0.458

High

124928

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

124930

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

124935

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.458

High

124984

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

124884

JUN
Transcription factor Jun

1

7

High-throughput

0.445

High

124925

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

124946

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.445

High

124969

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

124870

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.437

High

124871

TULP3
Tubby-related protein 3

1

1

High-throughput

0.437

High

124878

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.437

High

124880

MYCN
N-myc proto-oncogene protein

1

14

High-throughput

0.437

High

124881

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.437

High

124889

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

124890

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.437

High

124891

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.437

High

124893

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

124897

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

124902

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

124908

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

124932

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

124933

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

124942

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

124952

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

124956

CIC
Protein capicua homolog

1

7

High-throughput

0.437

High

124959

TGT
Queuine tRNA-ribosyltransferase catalytic subunit 1

1

1

High-throughput

0.437

High

124966

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

124979

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

124872

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

124943

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.426

High

124888

FOSL2
Fos-related antigen 2

1

1

High-throughput

0.407

High

124903

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.373

High

124958

CG025
UPF0415 protein C7orf25

2

0

High-throughput

0.316

High

124894

LYOX
Protein-lysine 6-oxidase

1

0

High-throughput

0.279

Low

124937

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

124876

CER1
Cerberus

1

0

High-throughput

0.249

Low

124939

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

124964

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025