HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBB (P0CG47)
Polyubiquitin-B [Cleaved into: Ubiquitin]
Gene: UBB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17719543
Identification Methods	enzymatic study
Interaction Type	enzymatic reaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 229
+	Hs
		475140 ITCH_HUMAN (1-870): 0: 902: 54.26		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		125113 WWP2_HUMAN (1-870): 0: 982: 100.00		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		125347 WWP2_HUMAN (1-870): 0: 982: 100.00		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	Hs
		476205 ITCH_HUMAN (1-870): 0: 902: 54.26		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Rn
		1140970 Q5YB86_RAT (11-870): 0: 876: 55.68		UBC_RAT (1-181): 2.6e-61: 206: 96.13
+	Hs
		476350 WWP1_HUMAN (1-870): 0: 888: 58.38		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		924156 WWP1_HUMAN (1-870): 0: 888: 58.38		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	Hs
		474953 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		476229 NED4L_HUMAN (5-867): 0: 785: 32.17		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		475470 NEDD4_HUMAN (90-867): 0: 731: 35.94		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		475080 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		397834 NEDD4_HUMAN (90-867): 0: 731: 35.94		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Sp
		143368 PTR1_SCHPO (411-868): 2.16e-163: 530: 34.86		UBI4P_SCHPO (1-228): 2.98e-90: 272: 96.05
+	Sc
		477424 TOM1_YEAST (494-869): 6.11e-158: 514: 40.26		UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05
+	Mm
		476858 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		UBC_MOUSE (1-181): 6.49e-62: 207: 96.13
+	Hs
		475984 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	At
		1091758 UPL1_ARATH (359-868): 4.41e-172: 555: 33.40		UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43
+	At
		1091762 UPL2_ARATH (374-868): 2.79e-170: 550: 33.91		UBQ3_ARATH (1-153): 2.79e-55: 180: 95.43
+	Mm
		924239 HUWE1_MOUSE (241-869): 2.82e-179: 576: 29.56		RS27A_MOUSE (153-228): 2.61e-44: 147: 100.00
+	Dm
		89879 D5SHR3_DROME (450-870): 3.31e-175: 514: 44.26		UBIQP_DROME (1-154): 5.32e-53: 183: 99.35