HitPredict

Interactor 1: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Interactor 2: CHD7 (Q9P2D1)
Chromodomain-helicase-DNA-binding protein 7 (CHD-7) (EC 3.6.4.12) (ATP-dependent helicase CHD7)
Gene: CHD7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	20130577, 21532573
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1214 Hs			1 2997
+	Hs
		1272954 SMRC1_HUMAN (4-1082): 0: 957: 60.83		CHD7_HUMAN (1-2997): 0: 2859: 100.00
+	Mm
		57189 SMRC2_MOUSE (1-1203): 0: 957: 96.51		CHD7_MOUSE (1-2997): 0: 2818: 94.26
+	Hs
		1018598 SMRC2_HUMAN (1-1203): 0: 992: 100.00		CHD3_HUMAN (549-1971): 0: 836: 26.40
+	Hs
		1059749 SMRC2_HUMAN (1-1203): 0: 992: 100.00		CHD4_HUMAN (607-1892): 0: 820: 26.91
+	Hs
		1018623 SMRC1_HUMAN (4-1082): 0: 957: 60.83		CHD3_HUMAN (549-1971): 0: 836: 26.40
+	Hs
		847025 SMRC2_HUMAN (1-1203): 0: 992: 100.00		SMCA4_HUMAN (232-1604): 0: 790: 22.42
+	Hs
		1059775 SMRC1_HUMAN (4-1082): 0: 957: 60.83		CHD4_HUMAN (607-1892): 0: 820: 26.91
+	Mm
		1111940 SMRC2_MOUSE (1-1203): 0: 957: 96.51		SMCA4_MOUSE (232-1604): 0: 796: 22.79
+	Mm
		956808 SMRC1_MOUSE (4-1028): 0: 952: 64.13		SMCA4_MOUSE (232-1604): 0: 796: 22.79
+	Hs
		847045 SMRC1_HUMAN (4-1082): 0: 957: 60.83		SMCA4_HUMAN (232-1604): 0: 790: 22.42
+	Sc
		697407 RSC8_YEAST (336-751): 4.61e-104: 342: 28.30		CHD1_YEAST (815-1973): 0: 851: 28.88
+	Sc
		744879 RSC8_YEAST (336-751): 4.61e-104: 342: 28.30		ISW1_YEAST (822-1900): 0: 818: 26.26
+	Hs
		1251632 SMRC2_HUMAN (1-1203): 0: 992: 100.00		CHD8_HUMAN (1-976): 4.16e-09: 65.1: 7.67
+	Hs
		1272944 SMRC1_HUMAN (4-1082): 0: 957: 60.83		CHD8_HUMAN (1-976): 4.16e-09: 65.1: 7.67
+	Hs
		232129 KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00		CHD3_HUMAN (549-1971): 0: 836: 26.40
+	Hs
		151359 KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00		CHD1_HUMAN (650-1969): 0: 824: 25.71
+	Hs
		232170 KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00		CHD4_HUMAN (607-1892): 0: 820: 26.91
+	Mm
		1111936 MYSM1_MOUSE (276-523): 3.33e-50: 194: 19.16		SMCA4_MOUSE (232-1604): 0: 796: 22.79
+	Mm
		1161068 KDM1A_MOUSE (254-543): 9.03e-44: 174: 15.05		CHD4_MOUSE (607-1892): 0: 810: 26.79
+	Hs
		232058 KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00		SMCA4_HUMAN (232-1604): 0: 790: 22.42