HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: UBE2K (P61086)
Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)
Gene: UBE2K

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22496338
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 200
+	Hs
		125262 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		125808 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72
+	Hs
		125335 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		125300 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		125655 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40
+	Hs
		125629 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40
+	Hs
		125263 WWP2_HUMAN (1-870): 0: 982: 100.00		UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74
+	Hs
		896355 ITCH_HUMAN (1-870): 0: 902: 54.26		UBE2K_HUMAN (1-200): 1.35e-82: 245: 100.00
+	Hs
		1294888 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D4_HUMAN (4-154): 1.49e-75: 225: 41.72
+	Hs
		849411 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		919827 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		895882 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		849444 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D1_HUMAN (4-154): 1.87e-75: 225: 39.74
+	Hs
		919860 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D2_HUMAN (4-154): 7.76e-75: 223: 41.06
+	Hs
		1294835 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E2_HUMAN (3-153): 3.57e-68: 208: 40.40
+	Hs
		1282329 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E3_HUMAN (3-153): 8.99e-68: 207: 40.40
+	Hs
		895910 WWP1_HUMAN (1-870): 0: 888: 58.38		UB2D3_HUMAN (4-154): 1.49e-73: 220: 39.74
+	Hs
		851871 ITCH_HUMAN (1-870): 0: 902: 54.26		UB2E1_HUMAN (3-153): 1.87e-66: 203: 39.74
+	Dm
		854579 SUDX_DROME (14-870): 0: 852: 52.14		UBCD2_DROME (3-153): 4.47e-68: 209: 41.72
+	Xl
		1151480 Q6GMD5_XENLA (2-867): 0: 792: 30.81		Q6WKX0_XENLA (3-153): 3.63e-68: 209: 40.40