Protein: DDX3Y
ATP-dependent RNA helicase DDX3Y (EC 3.6.4.13) (DEAD box protein 3, Y-chromosomal)

Gene: DDX3Y
Organism: Homo sapiens
Interactions: 87
UniProt ID: O15523

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003724 - RNA helicase activity
GO:0003729 - mRNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

193136

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

8

High-throughput

0.618

High

193075

RECQ4
ATP-dependent DNA helicase Q4

1

16

High-throughput

0.618

High

193100

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.618

High

193135

IGSF8
Immunoglobulin superfamily member 8

1

7

High-throughput

0.618

High

193133

NUDC2
NudC domain-containing protein 2

2

2

High-throughput

0.612

High

193117

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.553

High

193129

POC1A
POC1 centriolar protein homolog A

1

9

High-throughput

0.553

High

193077

CCNB2
G2/mitotic-specific cyclin-B2

1

2

High-throughput

0.536

High

193080

ESR1
Estrogen receptor

1

18

High-throughput

0.536

High

193083

RINI
Ribonuclease inhibitor

1

5

High-throughput

0.536

High

193086

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.536

High

193098

ERR3
Estrogen-related receptor gamma

1

10

High-throughput

0.536

High

193104

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

3

High-throughput

0.536

High

193105

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.536

High

193111

LEG9B
Galectin-9B

1

3

High-throughput

0.536

High

193112

ZSC23
Zinc finger and SCAN domain-containing protein 23

1

2

High-throughput

0.536

High

193116

DAB2P
Disabled homolog 2-interacting protein

1

3

High-throughput

0.536

High

193120

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

5

High-throughput

0.536

High

193122

RBM45
RNA-binding protein 45

1

10

High-throughput

0.536

High

193123

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

3

High-throughput

0.536

High

193128

RNF10
E3 ubiquitin-protein ligase RNF10

1

3

High-throughput

0.536

High

193134

RNF34
E3 ubiquitin-protein ligase RNF34

1

7

High-throughput

0.536

High

193137

BIRC7
Baculoviral IAP repeat-containing protein 7

1

6

High-throughput

0.536

High

193141

VPS35
Vacuolar protein sorting-associated protein 35

1

1

High-throughput

0.536

High

193149

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

5

High-throughput

0.536

High

193155

ST38L
Serine/threonine-protein kinase 38-like

1

1

High-throughput

0.536

High

193109

SMAD2
Mothers against decapentaplegic homolog 2

1

11

Small-scale

0.515

High

58688

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.513

High

193073

CLD3
Claudin-3

1

0

High-throughput

0.513

High

193078

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.513

High

193087

TSPO
Translocator protein

1

0

High-throughput

0.513

High

193089

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.513

High

193131

AF1L1
Actin filament-associated protein 1-like 1

1

0

High-throughput

0.513

High

193156

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

193139

ERP27
Endoplasmic reticulum resident protein 27

1

1

High-throughput

0.489

High

131237

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

9

Small-scale

0.479

High

156711

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.479

High

193076

HEXI1
Protein HEXIM1

1

5

High-throughput

0.479

High

193081

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

193084

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.479

High

193085

IF4B
Eukaryotic translation initiation factor 4B

1

6

Small-scale

0.479

High

193090

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.479

High

193091

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

193092

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

193094

MECP2
Methyl-CpG-binding protein 2

1

10

High-throughput

0.479

High

193095

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

8

High-throughput

0.479

High

193096

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

3

High-throughput

0.479

High

193097

CD81
CD81 antigen

1

3

High-throughput

0.479

High

193099

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.479

High

193101

SMAD3
Mothers against decapentaplegic homolog 3

1

11

Small-scale

0.479

High

193102

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

193106

MTF1
Metal regulatory transcription factor 1

1

3

High-throughput

0.479

High

193107

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

193108

PCBP1
Poly(rC)-binding protein 1

1

10

High-throughput

0.479

High

193110

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

193113

CRY2
Cryptochrome-2

1

6

High-throughput

0.479

High

193114

LARP7
La-related protein 7

1

15

High-throughput

0.479

High

193115

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.479

High

193119

MEPCE
7SK snRNA methylphosphate capping enzyme

1

5

High-throughput

0.479

High

193121

GOLI
E3 ubiquitin-protein ligase RNF130

1

4

High-throughput

0.479

High

193124

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

193126

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.479

High

193130

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

193138

CHM4C
Charged multivesicular body protein 4c

1

6

High-throughput

0.479

High

193140

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

193142

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

193143

RIOK1
Serine/threonine-protein kinase RIO1

1

7

High-throughput

0.479

High

193145

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

6

High-throughput

0.479

High

193146

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

193150

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

193152

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

193153

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

193093

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

193132

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

193144

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

193079

PAK4
Serine/threonine-protein kinase PAK 4

1

3

High-throughput

0.445

High

193088

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.445

High

193103

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.445

High

193127

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.445

High

193154

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

193082

SHBG
Sex hormone-binding globulin

1

3

Small-scale

0.439

High

193118

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

193147

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

193151

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.437

High

193074

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.279

Low

193125

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

0

High-throughput

0.279

Low

193148

CEP15
Centrosomal protein 15

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025