HitPredict

Interactor 1: PREX1 (Q8TCU6)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
Gene: PREX1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019899 - enzyme binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1659 Hs			1 530
+	Hs
		370063 PREX1_HUMAN (1-1659): 0: 2100: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377520 PREX1_HUMAN (1-1659): 0: 2100: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		1269784 ITSN2_HUMAN (5-520): 3.3e-95: 343: 19.14		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370586 ITSN2_HUMAN (5-520): 3.3e-95: 343: 19.14		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		50608 PKHG3_HUMAN (1-465): 3.76e-79: 289: 25.37		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		200765 ARHG9_HUMAN (6-418): 4.37e-89: 302: 28.10		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370229 FGD4_HUMAN (9-440): 1.2e-82: 291: 20.72		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		50543 PKHG3_HUMAN (1-465): 3.76e-79: 289: 25.37		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370679 VAV3_HUMAN (9-475): 2.21e-77: 277: 21.38		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369908 ARHG8_HUMAN (7-474): 3.07e-78: 273: 18.56		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370459 ECT2_HUMAN (17-442): 9.98e-74: 268: 18.99		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377746 ITSN2_HUMAN (5-520): 3.3e-95: 343: 19.14		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		166475 MCF2L_HUMAN (6-432): 1.11e-71: 265: 21.25		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		1269399 ARHGH_HUMAN (21-314): 1.3e-23: 111: 29.97		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		487102 VAV_HUMAN (6-487): 6.24e-83: 294: 20.04		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487829 VAV3_HUMAN (9-475): 2.21e-77: 277: 21.38		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487256 VAV2_HUMAN (1-457): 2.35e-74: 269: 21.67		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59