HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: CAC1C (Q13936)
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Gene: CACNA1C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	37207277
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 2221
+	Hs
		1047217 NED4L_HUMAN (5-867): 0: 785: 32.17		CAC1C_HUMAN (1-2221): 0: 1887: 100.00
+	Hs
		125457 WWP2_HUMAN (1-870): 0: 982: 100.00		SCN5A_HUMAN (1223-1776): 1.05e-19: 99.3: 14.35
+	Hs
		1055040 NED4L_HUMAN (5-867): 0: 785: 32.17		SCN5A_HUMAN (1223-1776): 1.05e-19: 99.3: 14.35
+	Hs
		808340 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCNAA_HUMAN (1205-1717): 6.96e-20: 100: 13.93
+	Hs
		808128 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN5A_HUMAN (1223-1776): 1.05e-19: 99.3: 14.35
+	Hs
		808322 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN8A_HUMAN (1228-1638): 2.18e-18: 95: 13.71
+	Hs
		723839 NEDD4_HUMAN (90-867): 0: 731: 35.94		SCN1A_HUMAN (1221-1814): 5.41e-16: 86.9: 12.33
+	Mm
		93276 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCNAA_MOUSE (1228-1731): 1.12e-19: 99.3: 14.72
+	Mm
		93284 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN8A_MOUSE (1228-1582): 7.45e-18: 93.1: 15.55
+	Mm
		69865 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN2A_MOUSE (1221-1548): 1.89e-17: 91.9: 16.20
+	Mm
		93274 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN9A_MOUSE (1223-1736): 3.53e-17: 91.2: 13.37
+	Mm
		93283 E9PXB7_MOUSE (151-867): 0: 684: 37.10		SCN5A_MOUSE (686-847): 2.05e-11: 72.2: 17.28
+	Mm
		808363 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCNAA_MOUSE (1228-1731): 1.12e-19: 99.3: 14.72
+	Mm
		808381 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN8A_MOUSE (1228-1582): 7.45e-18: 93.1: 15.55
+	Mm
		69867 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN2A_MOUSE (1221-1548): 1.89e-17: 91.9: 16.20
+	Mm
		808358 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN9A_MOUSE (1223-1736): 3.53e-17: 91.2: 13.37
+	Hs
		1055045 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SCN5A_HUMAN (1223-1776): 1.05e-19: 99.3: 14.35
+	Mm
		808378 NEDD4_MOUSE (14-364): 2.31e-51: 196: 19.16		SCN5A_MOUSE (686-847): 2.05e-11: 72.2: 17.28
+	Hs
		1079738 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SCN9A_HUMAN (1223-1768): 4e-18: 94.2: 13.18
+	Hs
		723851 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		SCN1A_HUMAN (1221-1814): 5.41e-16: 86.9: 12.33