HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: EREP1 (Q15884)
Endosomal transmembrane epsin interactor 1 (Endosomal transmembrane binding with epsin)
Gene: ENTREP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.50	0.669

Property	Details
Experiments	29892012, 25416956, 28514442, 33961781, 31515488, 34927784
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 450
+	Hs
		1079771 ITCH_HUMAN (1-870): 0: 902: 54.26		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079783 WWP1_HUMAN (1-870): 0: 888: 58.38		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079773 NED4L_HUMAN (5-867): 0: 785: 32.17		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		808136 NEDD4_HUMAN (90-867): 0: 731: 35.94		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		1079753 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		125597 WWP2_HUMAN (1-870): 0: 982: 100.00		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53
+	Hs
		946429 ITCH_HUMAN (1-870): 0: 902: 54.26		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946437 WWP1_HUMAN (1-870): 0: 888: 58.38		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1259694 WWP1_HUMAN (1-870): 0: 888: 58.38		Q8WU02_HUMAN (162-318): 1.1e-65: 210: 81.53
+	Hs
		946430 NED4L_HUMAN (5-867): 0: 785: 32.17		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		808086 NEDD4_HUMAN (90-867): 0: 731: 35.94		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		1079795 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		EREP1_HUMAN (1-450): 0: 619: 100.00
+	Hs
		946449 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38
+	Hs
		946405 HECW1_HUMAN (187-523): 3.02e-13: 76.4: 19.58		EREP3_HUMAN (3-317): 4.9e-89: 286: 26.38