HitPredict

Interactor 1: BRX1 (Q8TDN6)
Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)
Gene: BRIX1

Interactor 2: MAK16 (Q9BXY0)
Protein MAK16 homolog (NNP78) (Protein RBM13)
Gene: MAK16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Brix~Mak16
Common GO terms	GO:0003723 - RNA binding GO:0005730 - nucleolus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 300
+	Hs
		1315945 RPF1_HUMAN (13-269): 1.37e-72: 230: 20.83		MAK16_HUMAN (1-300): 3.14e-153: 432: 100.00
+	Hs
		1315944 RPF2_HUMAN (106-247): 1.01e-31: 122: 22.88		MAK16_HUMAN (1-300): 3.14e-153: 432: 100.00
+	Sc
		501260 BRX1_YEAST (40-305): 1.92e-92: 279: 45.32		MAK16_YEAST (3-235): 1.77e-86: 263: 48.73
+	Hs
		1315948 SSF1_HUMAN (54-228): 2.87e-21: 96.4: 15.22		MAK16_HUMAN (1-300): 3.14e-153: 432: 100.00
+	Dm
		1369296 RPF1_DROME (2-269): 2.45e-66: 216: 16.25		Q9W3B2_DROME (1-227): 6.82e-93: 280: 53.94
+	Sc
		501215 RPF1_YEAST (4-269): 5.6e-62: 201: 15.33		MAK16_YEAST (3-235): 1.77e-86: 263: 48.73
+	Sc
		501214 SSF1_YEAST (39-230): 7.36e-18: 86.4: 14.88		MAK16_YEAST (3-235): 1.77e-86: 263: 48.73
+	Sc
		501269 SSF2_YEAST (39-230): 1.83e-17: 84.9: 14.42		MAK16_YEAST (3-235): 1.77e-86: 263: 48.73
+	Sc
		501208 RPF2_YEAST (71-267): 1.62e-13: 72.5: 19.56		MAK16_YEAST (3-235): 1.77e-86: 263: 48.73