HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: DIDO1 (Q9BTC0)
Death-inducer obliterator 1 (DIO-1) (hDido1) (Death-associated transcription factor 1) (DATF-1)
Gene: DIDO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16189514
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 2240
+	Hs
		1311993 WWP1_HUMAN (1-870): 0: 888: 58.38		DIDO1_HUMAN (1-2240): 0: 732: 100.00
+	Mm
		1208066 WWP2_MOUSE (1-870): 0: 971: 95.98		DIDO1_MOUSE (1-2240): 0: 615: 70.28
+	Hs
		125817 WWP2_HUMAN (1-870): 0: 982: 100.00		PRC2C_HUMAN (27-1904): 3.9e-50: 199: 9.83
+	Hs
		125040 WWP2_HUMAN (1-870): 0: 982: 100.00		ANR17_HUMAN (1108-2079): 3.68e-42: 173: 12.34
+	Hs
		125249 WWP2_HUMAN (1-870): 0: 982: 100.00		YLPM1_HUMAN (1365-2223): 2.36e-41: 170: 13.66
+	Hs
		125793 WWP2_HUMAN (1-870): 0: 982: 100.00		PHF8_HUMAN (236-386): 7.12e-24: 112: 23.31
+	Hs
		1294841 ITCH_HUMAN (1-870): 0: 902: 54.26		MINT_HUMAN (10-2011): 1.36e-47: 191: 9.73
+	Hs
		125274 WWP2_HUMAN (1-870): 0: 982: 100.00		SC24C_HUMAN (1537-1898): 1.52e-16: 88.6: 19.74
+	Hs
		125795 WWP2_HUMAN (1-870): 0: 982: 100.00		SRRM2_HUMAN (6-1279): 6.35e-14: 80.3: 8.36
+	Dm
		1373179 SUDX_DROME (14-870): 0: 852: 52.14		Q9VRM6_DROME (1880-2234): 2.21e-19: 98.3: 17.12
+	Hs
		1299662 NED4L_HUMAN (5-867): 0: 785: 32.17		PHF8_HUMAN (236-386): 7.12e-24: 112: 23.31
+	Hs
		1299627 NED4L_HUMAN (5-867): 0: 785: 32.17		NSRP1_HUMAN (2033-2240): 4.74e-23: 108: 18.27
+	Hs
		808192 NEDD4_HUMAN (90-867): 0: 731: 35.94		TEANC_HUMAN (490-803): 1.1e-41: 159: 16.87
+	Hs
		808264 NEDD4_HUMAN (90-867): 0: 731: 35.94		NSRP1_HUMAN (2033-2240): 4.74e-23: 108: 18.27
+	Hs
		1312007 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		DIDO1_HUMAN (1-2240): 0: 732: 100.00
+	Hs
		1192175 HUWE1_HUMAN (241-869): 7.77e-179: 575: 30.03		CIC_HUMAN (2-1657): 2.53e-13: 78.4: 7.87
+	Hs
		1264807 SMUF2_HUMAN (1-363): 5.89e-43: 169: 17.62		TITIN_HUMAN (19-1290): 3.32e-21: 104: 10.49
+	Hs
		1267650 HECW2_HUMAN (154-531): 5.96e-16: 84.8: 17.23		PHF3_HUMAN (1921-2190): 3.11e-09: 64.7: 14.29