HitPredict

Interactor 1: ZN483 (Q8TF39)
Zinc finger protein 483 (Zinc finger protein with KRAB and SCAN domains 16)
Gene: ZNF483

Interactor 2: ZN496 (Q96IT1)
Zinc finger protein 496 (Zinc finger protein with KRAB and SCAN domains 17)
Gene: ZNF496

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	25416956, 33961781, 28514442
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SCAN~SCAN, zf-C2H2~zf-C2H2
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 744 Hs			1 587
+	Hs
		485184 ZN483_HUMAN (1-744): 0: 811: 100.00		ZSC22_HUMAN (363-586): 1.44e-95: 302: 26.34
+	Hs
		563724 ZN483_HUMAN (1-744): 0: 811: 100.00		ZKSC1_HUMAN (412-586): 9.38e-81: 266: 29.71
+	Hs
		1257092 ZN483_HUMAN (1-744): 0: 811: 100.00		ZKSC4_HUMAN (389-586): 2.45e-77: 256: 26.58
+	Hs
		1244153 ZN483_HUMAN (1-744): 0: 811: 100.00		ZN397_HUMAN (112-395): 1.84e-58: 205: 9.09
+	Hs
		563356 ZN483_HUMAN (1-744): 0: 811: 100.00		ZNF18_HUMAN (465-586): 6.19e-48: 177: 23.77
+	Hs
		1078408 ZN483_HUMAN (1-744): 0: 811: 100.00		ZKSC8_HUMAN (123-369): 1.44e-46: 174: 7.63
+	Hs
		1155987 ZN483_HUMAN (1-744): 0: 811: 100.00		ZSC25_HUMAN (483-587): 2.09e-34: 139: 21.91
+	Hs
		1257096 ZN483_HUMAN (1-744): 0: 811: 100.00		ZN446_HUMAN (31-485): 1.42e-29: 123: 30.57
+	Hs
		1257094 ZN483_HUMAN (1-744): 0: 811: 100.00		ZKSC3_HUMAN (103-312): 2.08e-19: 93.9: 6.57
+	Hs
		887251 ZN483_HUMAN (1-744): 0: 811: 100.00		ZN445_HUMAN (99-394): 2.66e-18: 91.2: 6.29
+	Hs
		1257100 ZN483_HUMAN (1-744): 0: 811: 100.00		ZN215_HUMAN (456-586): 7.63e-12: 69.7: 16.42
+	Hs
		152715 ZN483_HUMAN (1-744): 0: 811: 100.00		ZN197_HUMAN (101-287): 1.81e-09: 62.7: 5.79
+	Hs
		563643 ZN483_HUMAN (1-744): 0: 811: 100.00		ZNF24_HUMAN (399-485): 1.85e-09: 61.6: 37.93
+	Hs
		485174 Q6P088_HUMAN (1-240): 1.3e-166: 481: 100.00		ZSC22_HUMAN (363-586): 1.44e-95: 302: 26.34
+	Hs
		64162 ZN726_HUMAN (159-546): 2.05e-139: 425: 29.50		ZN430_HUMAN (260-570): 6.23e-113: 350: 18.37
+	Hs
		563279 ZNF16_HUMAN (239-743): 0: 648: 42.36		ZNF7_HUMAN (369-576): 5.39e-17: 86.7: 27.89
+	Hs
		1158016 Q6P088_HUMAN (1-240): 1.3e-166: 481: 100.00		ZN446_HUMAN (31-485): 1.42e-29: 123: 30.57
+	Hs
		3500 Q6P088_HUMAN (1-240): 1.3e-166: 481: 100.00		A0A0S2Z6X0_HUMAN (17-127): 5.08e-28: 111: 58.56
+	Hs
		1158015 Q6P088_HUMAN (1-240): 1.3e-166: 481: 100.00		ZN496_HUMAN (517-586): 7.3e-13: 73.1: 24.29
+	Hs
		563622 Q6P088_HUMAN (1-240): 1.3e-166: 481: 100.00		ZNF24_HUMAN (399-485): 1.85e-09: 61.6: 37.93