HitPredict

Interactor 1: CDC7 (O00311)
Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)
Gene: CDC7

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	9250678, 15232106
Identification Methods	enzymatic study, pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 574 Hs			1 808
+	Hs
		627214 GSK3B_HUMAN (9-376): 3.67e-74: 244: 16.67		MCM3_HUMAN (1-808): 0: 944: 100.00
+	Xl
		879180 Q9PWM7_XENLA (38-572): 2.37e-139: 414: 56.90		MCM2_XENLA (1-721): 0: 708: 31.11
+	Hs
		125859 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		125886 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Hs
		125851 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		625116 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM3_HUMAN (1-808): 0: 944: 100.00
+	Dm
		832234 Q9W3Y1_DROME (39-570): 1.13e-102: 327: 32.08		MCM2_DROME (10-668): 0: 677: 33.64
+	Hs
		125850 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		125852 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Dm
		1099480 Q9W3Y1_DROME (39-570): 1.13e-102: 327: 32.08		MCM4_DROME (28-664): 0: 649: 30.51
+	Hs
		835755 GSK3B_HUMAN (9-376): 3.67e-74: 244: 16.67		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Sp
		772833 HSK1_SCHPO (317-569): 1.6e-34: 138: 26.09		MCM2_SCHPO (1-668): 0: 674: 32.31
+	Sc
		412529 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM2_YEAST (6-668): 0: 664: 32.15
+	Sc
		412519 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM3_YEAST (45-782): 0: 655: 44.49
+	Sc
		412532 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM4_YEAST (9-804): 0: 654: 27.82
+	Hs
		625167 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		625168 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Sc
		412549 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM7_YEAST (20-674): 8.95e-91: 305: 34.27
+	Sp
		667322 HSK1_SCHPO (317-569): 1.6e-34: 138: 26.09		MCM4_SCHPO (109-652): 1.84e-87: 298: 34.15
+	Sc
		412530 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM5_YEAST (8-650): 1.72e-86: 292: 31.51