Protein: DIM1
Dimethyladenosine transferase (EC 2.1.1.183) (18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (18S rRNA dimethylase) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)

Gene: DIM1, DIMT1
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9UNQ2

Gene Ontology (top 5):
GO:0000179 - rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1462380

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.656

High

373497

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.656

High

397222

ESR1
Estrogen receptor

3

1

High-throughput

0.633

High

970171

RS16
Small ribosomal subunit protein uS9

2

1

High-throughput

0.611

High

1027849

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

1

High-throughput

0.611

High

1437407

LN28A
Protein lin-28 homolog A

2

2

High-throughput

0.601

High

1413874

THTPA
Thiamine-triphosphatase

2

0

High-throughput

0.585

High

810458

RL3
Large ribosomal subunit protein uL3

2

1

High-throughput

0.584

High

937970

FOXA1
Hepatocyte nuclear factor 3-alpha

2

1

High-throughput

0.584

High

1449410

SLX9
Ribosome biogenesis protein SLX9 homolog

2

0

High-throughput

0.576

High

541757

FGFR1
Fibroblast growth factor receptor 1

2

2

High-throughput

0.571

High

711203

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

0

High-throughput

0.559

High

1447442

ANLN
Anillin

2

0

High-throughput

0.559

High

522014

H14
Histone H1.4

1

2

High-throughput

0.536

High

694068

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

809917

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

985068

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

993028

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

1119036

BYST
Bystin

1

2

High-throughput

0.536

High

1291280

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

1402640

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.536

High

1415372

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.536

High

1437145

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

2

High-throughput

0.536

High

1438669

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.536

High

303661

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

391522

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

479490

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

788817

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

859503

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

884272

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

908477

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

1104336

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.513

High

1105724

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.513

High

1371150

IRF7
Interferon regulatory factor 7

1

0

High-throughput

0.513

High

1413416

RBM42
RNA-binding protein 42

1

0

High-throughput

0.513

High

1448458

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.513

High

1459777

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

191863

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.489

High

1462379

SRPK3
SRSF protein kinase 3

1

2

High-throughput

0.489

High

423460

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

135389

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

1

High-throughput

0.479

High

143327

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

157991

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

302668

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

316164

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

320147

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

346500

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

364028

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

406799

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

473182

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

474373

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.479

High

586953

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

607676

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.479

High

673980

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

799577

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

930082

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

3

High-throughput

0.479

High

954311

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

960300

RL26
Large ribosomal subunit protein uL24

1

2

High-throughput

0.479

High

969726

RS15A
Small ribosomal subunit protein uS8

1

1

High-throughput

0.479

High

979350

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

986278

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

994875

YBOX1
Y-box-binding protein 1

1

2

High-throughput

0.479

High

1088100

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1089604

ILF2
Interleukin enhancer-binding factor 2

1

1

High-throughput

0.479

High

1089925

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

1100542

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1135176

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1138170

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1207462

HABP4
Intracellular hyaluronan-binding protein 4

1

3

High-throughput

0.479

High

1335069

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1368678

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

1386747

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.479

High

1393824

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1411758

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

1421007

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

1429955

BRD8
Bromodomain-containing protein 8

1

1

High-throughput

0.479

High

1454359

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

1459315

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1461902

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1462385

MAGD1
Melanoma-associated antigen D1

1

2

High-throughput

0.479

High

1206576

PRC2B
Protein PRRC2B

1

0

High-throughput

0.460

High

129555

MEN1
Menin

1

0

High-throughput

0.458

High

158356

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

317949

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

344831

AP2A1
AP-2 complex subunit alpha-1

1

0

High-throughput

0.458

High

347999

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

447584

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

485514

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

558498

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

590031

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

612825

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

644129

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

687542

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.458

High

696862

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

765121

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

769512

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831649

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

858730

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

0

High-throughput

0.458

High

859729

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.458

High

872889

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

879615

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

913096

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

960945

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.458

High

971290

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

976025

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

982014

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

983086

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.458

High

983231

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

985386

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

1013896

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

1035993

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1062718

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

1092271

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1096277

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1107334

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1114658

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1118194

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

1138755

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1146870

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1151407

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1161441

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

1194454

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1197754

MIDN
Midnolin

1

0

High-throughput

0.458

High

1204292

DJC21
DnaJ homolog subfamily C member 21

1

0

High-throughput

0.458

High

1215896

RC3H1
Roquin-1

1

0

High-throughput

0.458

High

1238506

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1290817

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1329011

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1352835

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1363354

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.458

High

1363653

H1X
Histone H1.10

1

0

High-throughput

0.458

High

1364692

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1380253

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1386977

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.458

High

1390317

TRI11
E3 ubiquitin-protein ligase TRIM11

1

0

Small-scale

0.458

High

1397559

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1416091

REPI1
DNA-binding protein REPIN1

1

0

High-throughput

0.458

High

1420408

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

1428587

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

1429396

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1431343

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1447016

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1450875

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.458

High

1451464

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1462307

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

1462382

TR150
Thyroid hormone receptor-associated protein 3

1

0

High-throughput

0.458

High

1462384

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

430508

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

1227713

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

174640

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.437

High

787100

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

High-throughput

0.437

High

1087699

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

1

High-throughput

0.437

High

1126212

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1256098

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1276969

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1327272

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

1461694

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

1462383

MAFB
Transcription factor MafB

1

2

High-throughput

0.437

High

1401907

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1451895

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

High-throughput

0.426

High

1461377

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

887333

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

619954

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

389566

FINC
Fibronectin

1

0

High-throughput

0.279

Low

1462381

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

334596

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

0

Small-scale

0.249

Low

342371

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

554270

BMP4
Bone morphogenetic protein 4

1

0

High-throughput

0.249

Low

565489

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

627588

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

0

High-throughput

0.249

Low

1434233

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1214220

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025