Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD
Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.95 | 1.00 | 0.980 |
The method score is based on:
Property | Details |
---|---|
Experiments | 9113989, 26496610, 32296183, 35271311, 12147247, 21827948, 18641334, 31031754, 22020336, unassigned1304, 24165795 |
Identification Methods | pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, molecular sieving, protein kinase assay, mass spectrometry study of hydrogen/deuterium exchange, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid and 1 others
more... |
Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | PI3K_P85_iSH2~PI3_PI4_kinase, PI3_PI4_kinase~SH2, PI3K_C2~PI3K_P85_iSH2, PI3K_C2~SH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3Ka~SH2 |
Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005942 - phosphatidylinositol 3-kinase complex GO:0005943 - phosphatidylinositol 3-kinase complex, class IA and 4 others more... |
Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024