Interactor 1: PK3CD (O00329)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)
Gene: PIK3CD

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.980

The method score is based on:

Property Details
Experiments 9113989, 26496610, 32296183, 35271311, 12147247, 21827948, 18641334, 31031754, 22020336, unassigned1304, 24165795
Identification Methods pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, molecular sieving, protein kinase assay, mass spectrometry study of hydrogen/deuterium exchange, anti bait coimmunoprecipitation, two hybrid array, validated two hybrid and 1 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PI3K_P85_iSH2~PI3_PI4_kinase, PI3_PI4_kinase~SH2, PI3K_C2~PI3K_P85_iSH2, PI3K_C2~SH2, PI3K_P85_iSH2~PI3K_p85B, PI3K_P85_iSH2~PI3Ka, PI3Ka~SH2
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005942 - phosphatidylinositol 3-kinase complex
GO:0005943 - phosphatidylinositol 3-kinase complex, class IA
and 4 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1044
Hs

1 724
+ Mm
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+ Hs
+ Mm
+ Bt
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+ Hs
+ Bt
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+ Mm
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+ Mm
+ Dm
+ Dm
+ Ce

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Last updated: 15 Jul 2024