Protein: AP1B1
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)

Gene: AP1B1
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q10567

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001822 - kidney development
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1083291

AP2M1
AP-2 complex subunit mu

8

20

Small-scale

0.967

High

225805

AP1G1
AP-1 complex subunit gamma-1

6

15

Small-scale

0.938

High

1083323

NECP2
Adaptin ear-binding coat-associated protein 2

4

12

High-throughput

0.903

High

922570

AP2S1
AP-2 complex subunit sigma

4

20

High-throughput

0.892

High

940552

AP1S2
AP-1 complex subunit sigma-2

3

20

High-throughput

0.871

High

1083343

AP1M2
AP-1 complex subunit mu-2

3

20

High-throughput

0.861

High

1083305

AP1M1
AP-1 complex subunit mu-1

3

20

Small-scale

0.849

High

295736

AP1G2
AP-1 complex subunit gamma-like 2

2

14

High-throughput

0.793

High

988955

AP2B1
AP-2 complex subunit beta

2

13

High-throughput

0.789

High

1083280

NECP1
Adaptin ear-binding coat-associated protein 1

2

12

High-throughput

0.783

High

323709

AP2A2
AP-2 complex subunit alpha-2

2

14

High-throughput

0.776

High

1083233

EPN4
Clathrin interactor 1

4

20

Small-scale

0.696

High

344678

AP2A1
AP-2 complex subunit alpha-1

1

14

High-throughput

0.691

High

965408

AP1S1
AP-1 complex subunit sigma-1A

1

20

High-throughput

0.691

High

1083288

STON2
Stonin-2

1

20

High-throughput

0.691

High

1083296

AP1S3
AP-1 complex subunit sigma-3

1

20

High-throughput

0.691

High

1083309

KI13A
Kinesin-like protein KIF13A

3

11

Small-scale

0.675

High

363191

EGFR
Epidermal growth factor receptor

3

12

High-throughput

0.671

High

883045

AMPH
Amphiphysin

3

20

Small-scale

0.670

High

839751

EPS15
Epidermal growth factor receptor substrate 15

3

20

Small-scale

0.667

High

1083266

Q86V28
AP-1 complex subunit gamma

1

17

High-throughput

0.665

High

1014883

ARF1
ADP-ribosylation factor 1

1

20

Small-scale

0.647

High

1026002

CLH1
Clathrin heavy chain 1

1

11

Small-scale

0.647

High

273664

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

2

15

High-throughput

0.628

High

1083246

RUN3A
RUN domain-containing protein 3A

2

5

High-throughput

0.628

High

1083277

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

10

High-throughput

0.628

High

1083340

SNX9
Sorting nexin-9

2

6

High-throughput

0.628

High

975006

ARF6
ADP-ribosylation factor 6

1

20

High-throughput

0.618

High

1083228

AP1B1
AP-1 complex subunit beta-1

1

14

High-throughput

0.618

High

483080

CLCA
Clathrin light chain A

2

13

High-throughput

0.611

High

1083243

AAK1
AP2-associated protein kinase 1

2

20

High-throughput

0.611

High

1083251

CC183
Coiled-coil domain-containing protein 183

3

8

High-throughput

0.609

High

1083250

ARH
Low density lipoprotein receptor adapter protein 1

2

20

High-throughput

0.606

High

1083284

AGR3
Anterior gradient protein 3

2

6

High-throughput

0.606

High

563689

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.601

High

889269

NUMB
Protein numb homolog

2

20

Small-scale

0.601

High

1083237

RNPS1
RNA-binding protein with serine-rich domain 1

2

6

High-throughput

0.601

High

1083276

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

241516

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

630783

RAB4A
Ras-related protein Rab-4A

2

5

High-throughput

0.584

High

1083322

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.580

High

1083268

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.574

High

1083281

GP156
Probable G-protein coupled receptor 156

2

2

High-throughput

0.574

High

1083315

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.574

High

934528

TERA
Transitional endoplasmic reticulum ATPase

2

6

High-throughput

0.571

High

1083326

PLK2
Serine/threonine-protein kinase PLK2

1

6

Small-scale

0.561

High

1083321

BMP2K
BMP-2-inducible protein kinase

2

17

High-throughput

0.558

High

65879

MSGN1
Mesogenin-1

2

1

High-throughput

0.553

High

350452

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

6

High-throughput

0.553

High

827387

MLH1
DNA mismatch repair protein Mlh1

2

3

High-throughput

0.553

High

1005852

GTF2I
General transcription factor II-I

2

1

High-throughput

0.553

High

1028630

U2AF1
Splicing factor U2AF 35 kDa subunit

2

2

High-throughput

0.553

High

1083264

NUP54
Nucleoporin p54

2

3

High-throughput

0.553

High

1083294

P121A
Nuclear envelope pore membrane protein POM 121

2

7

High-throughput

0.553

High

1083310

RNF39
RING finger protein 39

2

1

High-throughput

0.553

High

1083334

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

1

High-throughput

0.553

High

529705

TAU
Microtubule-associated protein tau

2

18

High-throughput

0.552

High

1083240

NTRK2
BDNF/NT-3 growth factors receptor

1

15

High-throughput

0.541

High

155660

FCHO1
F-BAR domain only protein 1

1

10

High-throughput

0.536

High

215919

SYNJ1
Synaptojanin-1

1

11

High-throughput

0.536

High

271700

HIP1R
Huntingtin-interacting protein 1-related protein

1

5

High-throughput

0.536

High

483330

CLCB
Clathrin light chain B

1

11

High-throughput

0.536

High

642224

COMT
Catechol O-methyltransferase

1

2

High-throughput

0.536

High

711330

SHC1
SHC-transforming protein 1

1

17

High-throughput

0.536

High

1022105

SHC2
SHC-transforming protein 2

1

14

High-throughput

0.536

High

1070492

FCHO2
F-BAR domain only protein 2

1

10

High-throughput

0.536

High

1083232

CUL3
Cullin-3

1

6

High-throughput

0.536

High

1083238

RBP1
RalA-binding protein 1

1

11

High-throughput

0.536

High

1083239

ITSN1
Intersectin-1

1

20

High-throughput

0.536

High

1083259

AFTIN
Aftiphilin

1

2

High-throughput

0.536

High

1083290

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1083292

REPS1
RalBP1-associated Eps domain-containing protein 1

1

20

High-throughput

0.536

High

1083293

STALP
AMSH-like protease

1

1

High-throughput

0.536

High

1083295

SPT33
Spermatogenesis-associated protein 33

1

1

High-throughput

0.536

High

1083301

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

17

High-throughput

0.536

High

1083327

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.536

High

1083329

ITSN2
Intersectin-2

1

20

High-throughput

0.536

High

1083330

HTR5B
HEAT repeat-containing protein 5B

1

6

High-throughput

0.536

High

1083331

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

20

High-throughput

0.536

High

1083336

SYNRG
Synergin gamma

1

3

High-throughput

0.536

High

588553

RFA2
Replication protein A 32 kDa subunit

2

5

High-throughput

0.533

High

768049

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.533

High

1083324

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

5

Small-scale

0.527

High

1083229

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.516

High

1083335

FBX4
F-box only protein 4

1

0

High-throughput

0.513

High

650718

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

4

High-throughput

0.489

High

1058392

CKAP4
Cytoskeleton-associated protein 4

1

6

High-throughput

0.489

High

1083231

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.489

High

1083241

MEA1
Male-enhanced antigen 1

1

2

High-throughput

0.489

High

1083244

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1083248

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

14

High-throughput

0.489

High

1083283

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

1083299

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.489

High

1083307

WNK3
Serine/threonine-protein kinase WNK3

1

6

High-throughput

0.489

High

1083313

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

354958

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.484

High

1083297

FMNL2
Formin-like protein 2

1

4

High-throughput

0.481

High

139857

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

159625

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

8

High-throughput

0.479

High

172746

XPO1
Exportin-1

1

15

High-throughput

0.479

High

178254

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

218114

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.479

High

226008

STX6
Syntaxin-6

1

3

High-throughput

0.479

High

252760

AP180
Clathrin coat assembly protein AP180

1

15

Small-scale

0.479

High

324822

HEXI1
Protein HEXIM1

1

9

High-throughput

0.479

High

330908

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

400724

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

404010

GCR
Glucocorticoid receptor

1

14

High-throughput

0.479

High

411818

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

413716

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

445845

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

537053

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

562029

LAMP2
Lysosome-associated membrane glycoprotein 2

1

8

High-throughput

0.479

High

715562

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

731234

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

732561

ARRB2
Beta-arrestin-2

1

9

Small-scale

0.479

High

791343

SYUA
Alpha-synuclein

1

3

Small-scale

0.479

High

891496

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

976230

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

980724

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

988317

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

1031351

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

1067229

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

1083235

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1083236

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.479

High

1083242

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1083247

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

14

High-throughput

0.479

High

1083252

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1083253

LTOR1
Ragulator complex protein LAMTOR1

1

5

High-throughput

0.479

High

1083265

ATG9A
Autophagy-related protein 9A

1

5

High-throughput

0.479

High

1083275

RHG18
Rho GTPase-activating protein 18

1

9

High-throughput

0.479

High

1083279

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1083285

SMAP2
Stromal membrane-associated protein 2

1

9

High-throughput

0.479

High

1083286

PDC6I
Programmed cell death 6-interacting protein

1

11

High-throughput

0.479

High

1083289

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1083317

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

1083318

ANLN
Anillin

1

3

High-throughput

0.479

High

1083325

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

5

High-throughput

0.479

High

1083328

TLS1
Splicing factor C9orf78

1

5

High-throughput

0.479

High

1083332

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1083337

LAMP3
Lysosome-associated membrane glycoprotein 3

1

8

High-throughput

0.479

High

1083341

EPN1
Epsin-1

1

20

Small-scale

0.479

High

1083342

CABIN
Calcineurin-binding protein cabin-1

1

2

Small-scale

0.479

High

1083262

Q6ZN96
cDNA FLJ16308 fis, clone PUAEN2006335

1

4

High-throughput

0.470

High

880907

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

667812

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

688233

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.458

High

1083298

CCNL2
Cyclin-L2

1

0

High-throughput

0.458

High

1083312

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

1083338

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.458

High

224108

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

10

Small-scale

0.457

High

251746

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

11

Small-scale

0.457

High

171445

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.445

High

1033970

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

10

High-throughput

0.445

High

1083249

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1083254

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.445

High

1083256

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.445

High

1083257

NIPA3
Magnesium transporter NIPA3

1

2

High-throughput

0.445

High

1083270

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

1083282

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.445

High

1083302

S35A5
UDP-sugar transporter protein SLC35A5

1

1

High-throughput

0.445

High

1083308

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

1083339

SL9A8
Sodium/hydrogen exchanger 8

1

5

High-throughput

0.445

High

407807

SHBG
Sex hormone-binding globulin

1

2

Small-scale

0.439

High

1083300

BARD1
BRCA1-associated RING domain protein 1

1

7

High-throughput

0.439

High

105826

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

154481

CLD4
Claudin-4

1

1

Small-scale

0.437

High

160078

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

5

High-throughput

0.437

High

315515

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.437

High

353290

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

695308

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

1083258

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

3

High-throughput

0.437

High

1083260

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1083261

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.437

High

1083263

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1083267

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

1083271

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.437

High

1083273

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1083274

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

1083306

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1083311

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1083320

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

1083333

XPO7
Exportin-7

1

15

High-throughput

0.437

High

1083319

S17A5
Sialin

1

0

High-throughput

0.426

High

886799

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

1008111

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

Small-scale

0.408

High

1083230

ATR
Serine/threonine-protein kinase ATR

1

5

Small-scale

0.408

High

429789

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

1083255

S18B1
MFS-type transporter SLC18B1

1

2

High-throughput

0.407

High

1083269

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

4

High-throughput

0.407

High

1083287

S35F5
Solute carrier family 35 member F5

1

1

High-throughput

0.407

High

334403

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

922404

CRBB1
Beta-crystallin B1

2

0

High-throughput

0.316

High

1083245

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1083304

FND11
Fibronectin type III domain-containing protein 11

2

0

High-throughput

0.316

High

484508

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1083272

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

0

High-throughput

0.279

Low

1083278

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.279

Low

1083303

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

1083316

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1083314

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

519107

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

1083234

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025