Protein: CHD1
Chromodomain-helicase-DNA-binding protein 1 (CHD-1) (EC 3.6.4.-) (ATP-dependent helicase CHD1)

Gene: CHD1
Organism: Homo sapiens
Interactions: 128
UniProt ID: O14646

Gene Ontology (top 5):
GO:0000228 - nuclear chromosome
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

160068

H31
Histone H3.1

3

20

Small-scale

0.817

High

160071

H33
Histone H3.3

2

20

High-throughput

0.754

High

160072

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

16

High-throughput

0.691

High

160063

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

160066

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

160079

CBX3
Chromobox protein homolog 3

1

19

High-throughput

0.618

High

160084

DHX8
ATP-dependent RNA helicase DHX8

1

10

High-throughput

0.618

High

160099

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

160104

DHX40
Probable ATP-dependent RNA helicase DHX40

1

10

High-throughput

0.618

High

160112

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

160116

PHIP
PH-interacting protein

1

20

Small-scale

0.618

High

160120

FBXW7
F-box/WD repeat-containing protein 7

1

9

High-throughput

0.618

High

160123

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.618

High

160126

DDX23
Probable ATP-dependent RNA helicase DDX23

1

15

High-throughput

0.618

High

160143

FBW1B
F-box/WD repeat-containing protein 11

1

12

High-throughput

0.618

High

160145

FBW1A
F-box/WD repeat-containing protein 1A

1

12

Small-scale

0.618

High

160026

KDM1A
Lysine-specific histone demethylase 1A

1

20

Small-scale

0.604

High

160077

SSRP1
FACT complex subunit SSRP1

2

20

Small-scale

0.601

High

160119

FGF11
Fibroblast growth factor 11

2

5

High-throughput

0.601

High

160129

IN80B
INO80 complex subunit B

1

0

High-throughput

0.586

High

128610

MEN1
Menin

2

4

High-throughput

0.584

High

160028

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

160029

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.584

High

160035

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

160142

ZRAN1
Ubiquitin thioesterase ZRANB1

2

7

High-throughput

0.584

High

160036

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

160065

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

7

High-throughput

0.571

High

160125

RN157
E3 ubiquitin ligase RNF157

2

0

Small-scale

0.559

High

160031

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.552

High

160039

NPM
Nucleophosmin

1

4

High-throughput

0.536

High

160049

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.536

High

160056

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.536

High

160082

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

160118

FGF13
Fibroblast growth factor 13

1

5

High-throughput

0.536

High

160094

H31T
Histone H3.1t

1

20

High-throughput

0.527

High

160128

DOCK9
Dedicator of cytokinesis protein 9

2

1

High-throughput

0.521

High

160038

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.515

High

160124

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

5

Small-scale

0.500

High

160070

SRSF3
Serine/arginine-rich splicing factor 3

1

20

Small-scale

0.481

High

160091

SAFB1
Scaffold attachment factor B1

1

12

Small-scale

0.481

High

160140

BCLF1
Bcl-2-associated transcription factor 1

1

8

Small-scale

0.481

High

140660

NOP56
Nucleolar protein 56

1

9

High-throughput

0.479

High

156687

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

160023

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

160024

R113A
E3 ubiquitin-protein ligase RNF113A

1

3

High-throughput

0.479

High

160025

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

160027

HBP1
HMG box-containing protein 1

1

20

High-throughput

0.479

High

160032

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

160034

KI20A
Kinesin-like protein KIF20A

1

14

High-throughput

0.479

High

160037

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

160040

PARP1
Poly [ADP-ribose] polymerase 1

1

19

High-throughput

0.479

High

160041

GLI3
Transcriptional activator GLI3

1

5

High-throughput

0.479

High

160043

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.479

High

160044

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

160045

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

Small-scale

0.479

High

160046

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

160047

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

High-throughput

0.479

High

160048

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.479

High

160050

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

160051

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.479

High

160054

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

160055

COIL
Coilin

1

7

High-throughput

0.479

High

160057

GATA4
Transcription factor GATA-4

1

15

High-throughput

0.479

High

160058

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.479

High

160060

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

High-throughput

0.479

High

160061

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

13

High-throughput

0.479

High

160064

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

Small-scale

0.479

High

160067

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.479

High

160069

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

160073

KIF23
Kinesin-like protein KIF23

1

12

High-throughput

0.479

High

160074

ENL
Protein ENL

1

6

Small-scale

0.479

High

160075

SUH
Recombining binding protein suppressor of hairless

1

8

High-throughput

0.479

High

160080

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

160081

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

160087

CUL7
Cullin-7

1

3

High-throughput

0.479

High

160088

SUZ12
Polycomb protein SUZ12

1

8

High-throughput

0.479

High

160089

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

160090

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

160092

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.479

High

160095

LARP7
La-related protein 7

1

20

High-throughput

0.479

High

160097

TUT4
Terminal uridylyltransferase 4

1

2

High-throughput

0.479

High

160098

IFIX
Pyrin and HIN domain-containing protein 1

1

8

High-throughput

0.479

High

160101

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

160102

SLN11
Schlafen family member 11

1

2

High-throughput

0.479

High

160103

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

160105

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

160106

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.479

High

160107

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

8

High-throughput

0.479

High

160109

PAF1
RNA polymerase II-associated factor 1 homolog

1

5

Small-scale

0.479

High

160110

CGAS
Cyclic GMP-AMP synthase

1

7

High-throughput

0.479

High

160114

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

160115

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

160117

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

160130

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

4

High-throughput

0.479

High

160132

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

160134

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

160135

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

160137

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

11

High-throughput

0.479

High

160138

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

160139

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

160141

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

160146

ZN330
Zinc finger protein 330

1

4

High-throughput

0.479

High

160030

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

160062

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.458

High

160093

DUS5
Dual specificity protein phosphatase 5

1

0

High-throughput

0.458

High

160113

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

0

High-throughput

0.458

High

160121

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

160131

GBP3
Guanylate-binding protein 3

1

0

High-throughput

0.458

High

160136

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

160144

AGO1
Protein argonaute-1

1

0

High-throughput

0.458

High

160053

MERL
Merlin

1

7

High-throughput

0.445

High

160076

FMR1
Fragile X messenger ribonucleoprotein 1

1

14

High-throughput

0.445

High

160085

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

9

High-throughput

0.445

High

160096

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

160078

AP1B1
AP-1 complex subunit beta-1

1

5

High-throughput

0.437

High

160083

TRI29
Tripartite motif-containing protein 29

1

4

High-throughput

0.437

High

160086

GOGB1
Golgin subfamily B member 1

1

9

High-throughput

0.437

High

160100

CE128
Centrosomal protein of 128 kDa

1

17

High-throughput

0.437

High

160108

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

2

High-throughput

0.437

High

160122

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.437

High

160127

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.437

High

160111

IN80E
INO80 complex subunit E

1

0

High-throughput

0.426

High

160133

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.407

High

160033

WFS1
Wolframin

1

0

High-throughput

0.268

Low

160052

GRN
Progranulin

1

0

High-throughput

0.268

Low

160042

OSTP
Osteopontin

1

0

Small-scale

0.251

Low

160022

STX7
Syntaxin-7

1

0

High-throughput

0.249

Low

160059

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025