Interactor 1: VPS25 (Q7JXV9)
Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25) (Vacuolar protein sorting 25)
Gene: VPS25

Interactor 2: VPS36 (Q9VU87)
Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36)
Gene: VPS36

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.775

The method score is based on:

Property Details
Experiments 14605208, 38944040
Identification Methods two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains EAP30~ESCRT-II
Common GO terms GO:0000814 - ESCRT II complex
GO:0008104 - intracellular protein localization
GO:0042981 - regulation of apoptotic process
GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
and 1 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 174
Dm

1 399
+ Hs
+ At

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Last updated: 11Aug2025