HitPredict

Interactor 1: MADD (Q8WXG6)
MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)
Gene: MADD

Interactor 2: MTMR8 (Q96EF0)
Myotubularin-related protein 8 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Gene: MTMR8

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	27880917, 25659891
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1647 Hs			1 704
+	Hs
		1263666 MADD_HUMAN (1-1647): 0: 2403: 100.00		MTMR9_HUMAN (2-539): 0: 665: 34.38
+	Hs
		1263676 MADD_HUMAN (1-1647): 0: 2403: 100.00		MTMR4_HUMAN (28-581): 0: 602: 29.46
+	Hs
		309479 MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21		MTMR2_HUMAN (2-541): 0: 732: 37.89
+	Hs
		309478 MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21		MTMR1_HUMAN (2-542): 0: 725: 37.16
+	Hs
		1040909 MTMRD_HUMAN (10-658): 7.4e-124: 431: 18.73		MTMR2_HUMAN (2-541): 0: 732: 37.89
+	Hs
		1040871 MTMRD_HUMAN (10-658): 7.4e-124: 431: 18.73		MTMR1_HUMAN (2-542): 0: 725: 37.16
+	Dm
		1181856 Q7KSP6_DROME (10-676): 2.22e-120: 422: 20.09		Q9VMI9_DROME (10-555): 0: 683: 35.41
+	Hs
		309498 MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21		MTMRD_HUMAN (132-559): 1.46e-117: 389: 21.97
+	Hs
		309417 MTMR5_HUMAN (10-658): 1.04e-126: 440: 20.21		MTMR5_HUMAN (132-497): 1.35e-116: 387: 25.69