Protein: CD53
Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)

Gene: CD53
Organism: Homo sapiens
Interactions: 121
UniProt ID: P19397

Gene Ontology (top 5):
GO:0001772 - immunological synapse
GO:0005886 - plasma membrane
GO:0005911 - cell-cell junction
GO:0007165 - signal transduction
GO:0035579 - specific granule membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295671

UPK1B
Uroplakin-1b

2

17

High-throughput

0.783

High

535909

CD37
Leukocyte antigen CD37

2

19

High-throughput

0.783

High

622023

CD53
Leukocyte surface antigen CD53

2

19

High-throughput

0.783

High

622087

BT2A2
Butyrophilin subfamily 2 member A2

2

3

High-throughput

0.783

High

445476

CD2
T-cell surface antigen CD2

1

10

Small-scale

0.618

High

622026

CD9
CD9 antigen

1

19

Small-scale

0.618

High

622031

CD82
CD82 antigen

1

19

Small-scale

0.618

High

622040

CD81
CD81 antigen

1

19

Small-scale

0.618

High

328627

VAMP5
Vesicle-associated membrane protein 5

2

4

High-throughput

0.606

High

336152

CNIH1
Protein cornichon homolog 1

2

1

High-throughput

0.606

High

337860

CLD7
Claudin-7

2

6

High-throughput

0.606

High

423736

APOD
Apolipoprotein D

2

1

High-throughput

0.606

High

455949

ASGR2
Asialoglycoprotein receptor 2

2

9

High-throughput

0.606

High

622028

IBP5
Insulin-like growth factor-binding protein 5

2

1

High-throughput

0.606

High

622030

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

13

High-throughput

0.606

High

622033

STX2
Syntaxin-2

2

11

High-throughput

0.606

High

622036

CXA8
Gap junction alpha-8 protein

2

5

High-throughput

0.606

High

622038

EFNA5
Ephrin-A5

2

3

High-throughput

0.606

High

622039

EMP1
Epithelial membrane protein 1

2

4

High-throughput

0.606

High

622044

S35A1
CMP-sialic acid transporter

2

2

High-throughput

0.606

High

622045

PMP22
Peripheral myelin protein 22

2

4

High-throughput

0.606

High

622046

IFM3
Interferon-induced transmembrane protein 3

2

5

High-throughput

0.606

High

622047

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

622058

SGMR2
Sigma intracellular receptor 2

2

1

High-throughput

0.606

High

622060

F209A
Protein FAM209A

2

4

High-throughput

0.606

High

622064

CNIH2
Protein cornichon homolog 2

2

1

High-throughput

0.606

High

622066

VSTM1
V-set and transmembrane domain-containing protein 1

2

3

High-throughput

0.606

High

622077

CLD19
Claudin-19

2

6

High-throughput

0.606

High

622078

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

2

11

High-throughput

0.606

High

622082

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

4

High-throughput

0.606

High

622083

S7A14
Solute carrier family 7 member 14

2

6

High-throughput

0.606

High

622084

GP152
Probable G-protein coupled receptor 152

2

20

High-throughput

0.606

High

622101

CLC7A
C-type lectin domain family 7 member A

2

14

High-throughput

0.606

High

622114

AIG1
Androgen-induced gene 1 protein

2

2

High-throughput

0.606

High

622115

LPAR3
Lysophosphatidic acid receptor 3

2

19

High-throughput

0.606

High

129846

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.580

High

220351

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

590240

MUC1
Mucin-1

2

0

High-throughput

0.580

High

622049

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.580

High

622055

NKG7
Protein NKG7

2

0

High-throughput

0.580

High

622062

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

622093

MS4A3
Membrane-spanning 4-domains subfamily A member 3

2

0

High-throughput

0.580

High

622097

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

60555

TM218
Transmembrane protein 218

2

1

High-throughput

0.553

High

622032

CO4A5

2

1

High-throughput

0.553

High

622056

AR13B
ADP-ribosylation factor-like protein 13B

2

3

High-throughput

0.553

High

622057

CTXN3
Cortexin-3

2

1

High-throughput

0.553

High

622072

CD302
CD302 antigen

2

8

High-throughput

0.553

High

622075

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

3

High-throughput

0.553

High

622085

GPX8
Probable glutathione peroxidase 8

2

3

High-throughput

0.553

High

622089

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

6

High-throughput

0.553

High

622094

SIAT2
Beta-galactoside alpha-2,6-sialyltransferase 2

2

1

High-throughput

0.553

High

622098

CYBC1
Cytochrome b-245 chaperone 1

2

1

High-throughput

0.553

High

622102

SMIM3
Small integral membrane protein 3

2

1

High-throughput

0.553

High

622108

GP108
Protein GPR108

2

4

High-throughput

0.553

High

622109

SAR1A
Small COPII coat GTPase SAR1A

2

2

High-throughput

0.553

High

622112

TM140
Transmembrane protein 140

2

1

High-throughput

0.553

High

622048

KDSR
3-ketodihydrosphingosine reductase

2

11

High-throughput

0.549

High

622070

RETR3
Reticulophagy regulator 3

2

6

High-throughput

0.549

High

622088

TM186
Transmembrane protein 186

2

3

High-throughput

0.549

High

622095

F210B
Protein FAM210B, mitochondrial

2

6

High-throughput

0.549

High

217814

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.536

High

622042

RAP1A
Ras-related protein Rap-1A

1

2

High-throughput

0.536

High

622054

VAMP3
Vesicle-associated membrane protein 3

1

4

High-throughput

0.536

High

622092

ALG14
UDP-N-acetylglucosamine transferase subunit ALG14

1

1

High-throughput

0.536

High

516895

ECE2
Endothelin-converting enzyme 2

1

8

High-throughput

0.515

High

622081

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.489

High

622090

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

2

High-throughput

0.489

High

622096

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

3

High-throughput

0.489

High

622113

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

3

High-throughput

0.489

High

622117

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

1

High-throughput

0.489

High

622073

TARG1
Trafficking regulator of GLUT4 1

1

2

High-throughput

0.481

High

622104

CXL16
C-X-C motif chemokine 16

1

1

High-throughput

0.481

High

603156

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.479

High

622024

GGT1
Glutathione hydrolase 1 proenzyme

1

2

Small-scale

0.479

High

63634

A5PKU2
TUSC5 protein

1

2

High-throughput

0.470

High

66061

RP1BL
Ras-related protein Rap-1b-like protein

1

3

High-throughput

0.445

High

520674

RRAS
Ras-related protein R-Ras

1

6

High-throughput

0.445

High

609570

LEG3
Galectin-3

1

11

High-throughput

0.445

High

622034

BMR1A
Bone morphogenetic protein receptor type-1A

1

5

High-throughput

0.445

High

622035

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

3

High-throughput

0.445

High

622041

RRAS2
Ras-related protein R-Ras2

1

7

High-throughput

0.445

High

622053

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

7

High-throughput

0.445

High

622061

WLS
Protein wntless homolog

1

5

High-throughput

0.445

High

622063

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

1

High-throughput

0.445

High

622065

SCIMP
SLP adapter and CSK-interacting membrane protein

1

1

Small-scale

0.445

High

622068

CCD81
Coiled-coil domain-containing protein 81

1

1

Small-scale

0.445

High

622069

TAXB1
Tax1-binding protein 1

1

8

High-throughput

0.445

High

622086

RAB2B
Ras-related protein Rab-2B

1

2

High-throughput

0.445

High

622099

TACAN
Transmembrane protein 120A

1

1

High-throughput

0.445

High

622106

E41L5
Band 4.1-like protein 5

1

6

High-throughput

0.445

High

622107

KC1G1
Casein kinase I isoform gamma-1

1

1

High-throughput

0.445

High

622111

LRC4B
Leucine-rich repeat-containing protein 4B

1

3

High-throughput

0.445

High

622118

PCDGD
Protocadherin gamma-B1

1

2

High-throughput

0.445

High

622027

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.426

High

622052

ASAH1
Acid ceramidase

1

0

High-throughput

0.426

High

127275

LEG8
Galectin-8

1

11

High-throughput

0.407

High

622050

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

5

High-throughput

0.407

High

622103

RBM38
RNA-binding protein 38

1

4

High-throughput

0.407

High

58646

SRTM1
Serine-rich and transmembrane domain-containing protein 1

2

0

High-throughput

0.316

High

622025

MAL
Myelin and lymphocyte protein

2

0

High-throughput

0.316

High

622029

PPLA
Phospholamban

2

0

High-throughput

0.316

High

622037

CLCN7
H(+)/Cl(-) exchange transporter 7

2

0

High-throughput

0.316

High

622051

BIK
Bcl-2-interacting killer

2

0

High-throughput

0.316

High

622059

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

622067

SNORC
Protein SNORC

2

0

High-throughput

0.316

High

622071

C1QL4
Complement C1q-like protein 4

2

0

High-throughput

0.316

High

622076

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

622079

LSME1
Leucine-rich single-pass membrane protein 1

2

0

High-throughput

0.316

High

622080

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

622091

GIMA5
GTPase IMAP family member 5

2

0

High-throughput

0.316

High

622100

B2L13
Bcl-2-like protein 13

2

0

High-throughput

0.316

High

622105

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

622110

RPRM
Protein reprimo

2

0

High-throughput

0.316

High

622116

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.316

High

622119

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.316

High

71289

F1712
Protein FAM171A2

2

0

High-throughput

0.313

High

516252

DWORF
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF

1

0

High-throughput

0.268

Low

622043

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.232

Low

622074

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025