HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1164 Hs			1 669
+	Hs
		61869 TSC1_HUMAN (1-1164): 0: 725: 100.00		CC88B_HUMAN (60-668): 4.55e-16: 84.7: 12.48
+	Hs
		1012570 CGNL1_HUMAN (280-1054): 5.93e-34: 144: 11.22		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Rn
		655923 DCTN1_RAT (540-1022): 4.75e-54: 209: 16.13		DCTN1_RAT (198-655): 6.79e-29: 125: 17.56
+	Hs
		1268083 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		724989 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		LZTS2_HUMAN (1-669): 6.28e-56: 203: 100.00
+	Hs
		1051273 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		148801 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		1012560 CGNL1_HUMAN (280-1054): 5.93e-34: 144: 11.22		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		1268099 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MYO5C_HUMAN (318-668): 7.57e-17: 87.4: 12.02
+	Hs
		528395 CACO1_HUMAN (620-1116): 8.08e-29: 126: 14.93		MYH6_HUMAN (140-554): 2.32e-09: 63.1: 9.14
+	Hs
		148466 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		725097 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79
+	Hs
		1268060 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		1268126 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MRCKB_HUMAN (197-560): 2.09e-10: 66.2: 13.44
+	Hs
		724943 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		1068617 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		149126 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		724839 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		PLEC_HUMAN (327-659): 1.61e-09: 63.5: 20.77
+	Hs
		148460 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		724687 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79