Protein: P4HA3
Prolyl 4-hydroxylase subunit alpha-3 (4-PH alpha-3) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3)

Gene: P4HA3
Organism: Homo sapiens
Interactions: 153
UniProt ID: Q7Z4N8

Gene Ontology (top 5):
GO:0004656 - procollagen-proline 4-dioxygenase activity
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0030199 - collagen fibril organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452312

PDIA1
Protein disulfide-isomerase

3

11

High-throughput

0.855

High

180155

ZBT7B
Zinc finger and BTB domain-containing protein 7B

5

3

High-throughput

0.653

High

637916

NF1
Neurofibromin

3

0

High-throughput

0.634

High

535238

BIP
Endoplasmic reticulum chaperone BiP

2

2

High-throughput

0.628

High

848203

MAGA2
Melanoma-associated antigen 2

4

3

High-throughput

0.623

High

1094292

PDIA2
Protein disulfide-isomerase A2

1

11

Small-scale

0.618

High

169621

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

2

High-throughput

0.616

High

71347

F1712
Protein FAM171A2

3

1

High-throughput

0.604

High

325912

UBR5
E3 ubiquitin-protein ligase UBR5

3

1

High-throughput

0.604

High

890850

TSC2
Tuberin

3

2

High-throughput

0.604

High

1198304

TIGD5
Tigger transposable element-derived protein 5

3

2

High-throughput

0.604

High

1253846

SRCAP
Helicase SRCAP

3

4

High-throughput

0.604

High

1272101

RSRC2
Arginine/serine-rich coiled-coil protein 2

3

1

High-throughput

0.604

High

1278527

KI21A
Kinesin-like protein KIF21A

3

2

High-throughput

0.604

High

1278537

ZN687
Zinc finger protein 687

3

2

High-throughput

0.604

High

1278549

CSKI2
Caskin-2

3

2

High-throughput

0.604

High

1278593

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

3

1

High-throughput

0.604

High

1278596

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

3

3

High-throughput

0.593

High

1212665

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.580

High

888632

YLPM1
YLP motif-containing protein 1

2

3

High-throughput

0.574

High

1115542

ASPP2
Apoptosis-stimulating of p53 protein 2

2

2

High-throughput

0.574

High

1238263

PWP2B
PWWP domain-containing protein 2B

2

1

High-throughput

0.574

High

1278534

SRRM1
Serine/arginine repetitive matrix protein 1

2

1

High-throughput

0.574

High

1278535

ZN444
Zinc finger protein 444

2

2

High-throughput

0.574

High

1278542

RB15B
Putative RNA-binding protein 15B

2

1

High-throughput

0.574

High

1278550

ZN592
Zinc finger protein 592

2

2

High-throughput

0.574

High

1278555

PWP2A
PWWP domain-containing protein 2A

2

1

High-throughput

0.574

High

1278565

WDR33
pre-mRNA 3' end processing protein WDR33

2

5

High-throughput

0.574

High

1278575

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.574

High

1278587

MAGC2
Melanoma-associated antigen C2

2

3

High-throughput

0.573

High

63222

VP37C
Vacuolar protein sorting-associated protein 37C

2

1

High-throughput

0.553

High

336703

BAG4
BAG family molecular chaperone regulator 4

2

1

High-throughput

0.553

High

1251856

SCAR5
Scavenger receptor class A member 5

2

5

High-throughput

0.553

High

1278556

TOX2
TOX high mobility group box family member 2

2

2

High-throughput

0.553

High

1278563

RUSC1
AP-4 complex accessory subunit RUSC1

2

1

High-throughput

0.553

High

1278564

C1QT2
Complement C1q tumor necrosis factor-related protein 2

2

8

High-throughput

0.553

High

1278578

RFOX1
RNA binding protein fox-1 homolog 1

2

1

High-throughput

0.553

High

1278582

GGA3
ADP-ribosylation factor-binding protein GGA3

2

2

High-throughput

0.553

High

1278586

LR2BP
LRP2-binding protein

2

2

High-throughput

0.553

High

1122273

SCRIB
Protein scribble homolog

2

1

High-throughput

0.549

High

1278559

NECD
Necdin

2

6

High-throughput

0.533

High

214590

WDR62
WD repeat-containing protein 62

1

1

High-throughput

0.523

High

997824

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.489

High

1278533

YAF2
YY1-associated factor 2

1

1

High-throughput

0.489

High

1278568

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.489

High

218388

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

242131

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

1199070

Q53GC0
SERTA domain containing 1 variant

1

1

High-throughput

0.470

High

1278528

Q86V38
Atrophin 1

1

3

High-throughput

0.470

High

1278552

Q96E03
Melanoma antigen family A, 2B

1

3

High-throughput

0.470

High

1278581

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.445

High

928293

ATN1
Atrophin-1

1

4

High-throughput

0.439

High

1278589

SRTD1
SERTA domain-containing protein 1

1

1

High-throughput

0.439

High

287579

LRP6
Low-density lipoprotein receptor-related protein 6

1

0

High-throughput

0.426

High

1085334

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

0

High-throughput

0.426

High

1157366

EXT1
Exostosin-1

1

0

High-throughput

0.426

High

3252

A0A0S2Z3Y6
Necdin-like protein isoform 3

1

3

High-throughput

0.417

High

3258

A0A0S2Z442
Necdin-like protein isoform 4

1

3

High-throughput

0.417

High

1278600

X5D2Y6
Necdin isoform B

1

3

High-throughput

0.417

High

49970

RHG10
Rho GTPase-activating protein 10

1

3

High-throughput

0.407

High

51091

PKHG3
Pleckstrin homology domain-containing family G member 3

1

3

High-throughput

0.407

High

95984

E7EUN2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.407

High

244262

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.407

High

290331

KS6A4
Ribosomal protein S6 kinase alpha-4

1

1

High-throughput

0.407

High

841054

HELZ
Probable helicase with zinc finger domain

1

1

High-throughput

0.407

High

964659

DCAF7
DDB1- and CUL4-associated factor 7

1

5

High-throughput

0.407

High

1217690

SYDE2
Rho GTPase-activating protein SYDE2

1

3

High-throughput

0.407

High

1218243

F1711
Protein FAM171A1

1

1

High-throughput

0.407

High

1258448

CHSS3
Chondroitin sulfate synthase 3

1

3

High-throughput

0.407

High

1278530

CHSS1
Chondroitin sulfate synthase 1

1

3

High-throughput

0.407

High

1278536

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

1

High-throughput

0.407

High

1278538

SYNPO
Synaptopodin

1

2

High-throughput

0.407

High

1278540

UXS1
UDP-glucuronic acid decarboxylase 1

1

1

High-throughput

0.407

High

1278545

DLG5
Disks large homolog 5

1

1

High-throughput

0.407

High

1278546

ARH40
Rho guanine nucleotide exchange factor 40

1

5

High-throughput

0.407

High

1278554

SREC2
Scavenger receptor class F member 2

1

1

High-throughput

0.407

High

1278557

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

1

3

High-throughput

0.407

High

1278558

ARHGH
Rho guanine nucleotide exchange factor 17

1

1

High-throughput

0.407

High

1278561

FSP1
Ferroptosis suppressor protein 1

1

1

High-throughput

0.407

High

1278569

PKHG2
Pleckstrin homology domain-containing family G member 2

1

3

High-throughput

0.407

High

1278584

RHG23
Rho GTPase-activating protein 23

1

3

High-throughput

0.407

High

1278585

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.407

High

1203980

ZC12A
Endoribonuclease ZC3H12A

3

0

High-throughput

0.352

High

1278531

NUTM1
NUT family member 1

3

0

High-throughput

0.348

High

278883

PEX14
Peroxisomal membrane protein PEX14

3

0

High-throughput

0.345

High

1155299

VPS72
Vacuolar protein sorting-associated protein 72 homolog

3

0

High-throughput

0.345

High

1278571

FBRS
Probable fibrosin-1

3

0

High-throughput

0.345

High

1278574

DMAP1
DNA methyltransferase 1-associated protein 1

3

0

High-throughput

0.345

High

1278588

TRPS1
Zinc finger transcription factor Trps1

3

0

High-throughput

0.345

High

1278594

KMT2B
Histone-lysine N-methyltransferase 2B

3

0

High-throughput

0.345

High

1278598

MTCL1
Microtubule cross-linking factor 1

3

0

High-throughput

0.345

High

211651

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.328

High

340355

YETS4
YEATS domain-containing protein 4

2

0

High-throughput

0.328

High

900388

FXR2
RNA-binding protein FXR2

2

0

High-throughput

0.328

High

1032764

SATB1
DNA-binding protein SATB1

2

0

High-throughput

0.328

High

1094699

CAF1A
Chromatin assembly factor 1 subunit A

2

0

High-throughput

0.328

High

1126823

SLBP
Histone RNA hairpin-binding protein

2

0

High-throughput

0.328

High

1150747

SF01
Splicing factor 1

2

0

High-throughput

0.328

High

1218183

ZN318
Zinc finger protein 318

2

0

High-throughput

0.328

High

1231413

ZN787
Zinc finger protein 787

2

0

High-throughput

0.328

High

1278529

SESD1
SEC14 domain and spectrin repeat-containing protein 1

2

0

High-throughput

0.328

High

1278539

ZN579
Zinc finger protein 579

2

0

High-throughput

0.328

High

1278541

NF2IP
NFATC2-interacting protein

2

0

High-throughput

0.328

High

1278543

PPHLN
Periphilin-1

2

0

High-throughput

0.328

High

1278547

HASP
Serine/threonine-protein kinase haspin

2

0

High-throughput

0.328

High

1278566

ARP6
Actin-related protein 6

2

0

High-throughput

0.328

High

1278572

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

0

High-throughput

0.328

High

1278573

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.328

High

1278579

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

2

0

High-throughput

0.328

High

162106

ACOT8
Acyl-coenzyme A thioesterase 8

2

0

High-throughput

0.316

High

217133

MS18B
Protein Mis18-beta

2

0

High-throughput

0.316

High

277116

PROP1
Homeobox protein prophet of Pit-1

2

0

High-throughput

0.316

High

605143

KCRS
Creatine kinase S-type, mitochondrial

2

0

High-throughput

0.316

High

616701

ADA2C
Alpha-2C adrenergic receptor

2

0

High-throughput

0.316

High

700917

PSB4
Proteasome subunit beta type-4

2

0

High-throughput

0.316

High

948245

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

1006268

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.316

High

1061753

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

1162397

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.316

High

1186570

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.316

High

1186880

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

1246475

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.316

High

1278532

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

1278548

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.316

High

1278551

F136A
Protein FAM136A

2

0

High-throughput

0.316

High

1278560

B9D2
B9 domain-containing protein 2

2

0

High-throughput

0.316

High

1278562

NICN1
Nicolin-1

2

0

High-throughput

0.316

High

1278576

CNBP1
Beta-catenin-interacting protein 1

2

0

High-throughput

0.316

High

1278577

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

0

High-throughput

0.316

High

1278580

APC11
Anaphase-promoting complex subunit 11

2

0

High-throughput

0.316

High

1278583

STMN3
Stathmin-3

2

0

High-throughput

0.316

High

1278590

MSRA
Mitochondrial peptide methionine sulfoxide reductase

2

0

High-throughput

0.316

High

1278591

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.316

High

1278599

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High

341974

CEP43
Centrosomal protein 43

2

0

High-throughput

0.313

High

893975

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.299

High

1278553

DTBP1
Dysbindin

1

0

High-throughput

0.299

High

219639

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.279

Low

1149413

SIX1
Homeobox protein SIX1

1

0

High-throughput

0.279

Low

1278567

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.279

Low

1278597

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

321770

AGRL1
Adhesion G protein-coupled receptor L1

1

0

High-throughput

0.232

Low

448043

ITAV
Integrin alpha-V

1

0

High-throughput

0.232

Low

774777

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.232

Low

832997

ETV6
Transcription factor ETV6

1

0

High-throughput

0.232

Low

1008075

DEN2B
DENN domain-containing protein 2B

1

0

High-throughput

0.232

Low

1103768

PLD1
Phospholipase D1

1

0

High-throughput

0.232

Low

1178982

SHRM1
Protein Shroom1

1

0

High-throughput

0.232

Low

1208925

DCA10
DDB1- and CUL4-associated factor 10

1

0

High-throughput

0.232

Low

1278544

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.232

Low

1278570

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.232

Low

1278592

ZDHC8
Palmitoyltransferase ZDHHC8

1

0

High-throughput

0.232

Low

1278595

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025