HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1164 Hs			1 389
+	Hs
		1267521 TSC1_HUMAN (1-1164): 0: 725: 100.00		HSH2D_HUMAN (76-257): 5.81e-43: 154: 31.32
+	Hs
		924566 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		728465 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		924736 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433620 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		412287 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		724756 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		111443 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		J3QRU1_HUMAN (7-280): 1.3e-46: 168: 16.56
+	Hs
		433272 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		148506 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		412058 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		433558 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		523231 MYH4_HUMAN (393-969): 2.58e-19: 96.8: 11.22		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		411983 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		411581 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		433818 MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		434101 MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		433749 ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		411758 MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		411908 MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31