HitPredict

Interactor 1: PTPRU (Q92729)
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)
Gene: PTPRU

Interactor 2: CLC2D (Q9UHP7)
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Gene: CLEC2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	fn3~Lectin_C
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1446 Hs			1 191
+	Hs
		1100775 PTPRU_HUMAN (1-1446): 0: 1131: 100.00		CL12B_HUMAN (67-191): 2.26e-37: 132: 27.94
+	Hs
		644614 PTPRU_HUMAN (1-1446): 0: 1131: 100.00		NKG2A_HUMAN (23-188): 8.34e-38: 132: 19.77
+	Hs
		1069991 PTPRK_HUMAN (26-1442): 0: 1098: 59.48		CLC4A_HUMAN (42-191): 3.17e-38: 133: 18.79
+	Hs
		149944 PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64		NCAN_HUMAN (14-189): 2.18e-45: 161: 16.11
+	Hs
		489893 PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64		CSPG2_HUMAN (52-189): 1.21e-42: 154: 20.67
+	Hs
		490037 PTPRF_HUMAN (7-941): 1.88e-67: 254: 11.64		CLC4A_HUMAN (42-191): 3.17e-38: 133: 18.79
+	Mm
		420375 PTPRC_MOUSE (77-1205): 1.67e-71: 265: 13.45		MRC1_MOUSE (51-186): 3.94e-15: 74.7: 13.70
+	Hs
		59752 PTPRS_HUMAN (187-943): 1.73e-38: 160: 10.32		KLRG2_HUMAN (33-186): 7.9e-44: 152: 28.93