HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: LMBL2 (Q969R5)
Lethal(3)malignant brain tumor-like protein 2 (H-l(3)mbt-like protein 2) (L(3)mbt-like protein 2)
Gene: L3MBTL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 27705803, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 705
+	Mm
		886477 HDAC2_MOUSE (1-488): 0: 704: 99.39		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Hs
		1038604 HDAC1_HUMAN (1-443): 0: 642: 90.07		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Mm
		140246 HDAC1_MOUSE (1-443): 0: 645: 90.29		LMBL2_MOUSE (1-705): 0: 1001: 90.92
+	Hs
		177350 HDAC3_HUMAN (10-431): 0: 574: 58.26		LMBL2_HUMAN (1-705): 0: 1012: 100.00
+	Hs
		1270507 HDAC2_HUMAN (1-488): 0: 707: 100.00		SMBT1_HUMAN (160-638): 0: 556: 32.19
+	Hs
		1038787 HDAC1_HUMAN (1-443): 0: 642: 90.07		SMBT1_HUMAN (160-638): 0: 556: 32.19
+	Hs
		1270377 HDAC2_HUMAN (1-488): 0: 707: 100.00		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Dm
		1276540 HDAC1_DROME (5-472): 0: 653: 77.92		SMBT_DROME (138-401): 4.84e-35: 145: 21.17
+	Hs
		1038627 HDAC1_HUMAN (1-443): 0: 642: 90.07		LMBL3_HUMAN (140-285): 2.23e-26: 117: 26.03
+	Dm
		1276533 HDAC1_DROME (5-472): 0: 653: 77.92		Q9VB52_DROME (148-294): 5.52e-17: 87.9: 22.45