Protein: LEO1
RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)

Gene: LEO1
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q8WVC0

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001711 - endodermal cell fate commitment
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1330543

PAF1
RNA polymerase II-associated factor 1 homolog

15

10

Small-scale

0.984

High

1240664

CDC73
Parafibromin

14

3

Small-scale

0.760

High

1243831

CTR9
RNA polymerase-associated protein CTR9 homolog

9

6

Small-scale

0.751

High

1357911

SKI8
Superkiller complex protein 8

6

6

Small-scale

0.732

High

1124382

ELOA1
Elongin-A

3

2

Small-scale

0.656

High

1357902

RTF1
RNA polymerase-associated protein RTF1 homolog

3

2

Small-scale

0.650

High

654661

TCEA1
Transcription elongation factor A protein 1

2

2

Small-scale

0.643

High

130556

SPT5H
Transcription elongation factor SPT5

2

2

High-throughput

0.628

High

521834

H14
Histone H1.4

2

2

High-throughput

0.628

High

292320

TCEA3
Transcription elongation factor A protein 3

2

4

High-throughput

0.606

High

667380

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

2

Small-scale

0.585

High

711167

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

1

Small-scale

0.584

High

786747

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

1

High-throughput

0.584

High

1244625

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

596264

H12
Histone H1.2

1

2

Small-scale

0.561

High

997892

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.550

High

908217

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.547

High

542130

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

621692

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.536

High

872576

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

909359

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

2

Small-scale

0.536

High

952985

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

967878

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.536

High

1006927

KC1G2
Casein kinase I isoform gamma-2

1

3

High-throughput

0.536

High

1041566

KMT2A
Histone-lysine N-methyltransferase 2A

1

1

Small-scale

0.536

High

1065320

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1117614

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.536

High

1163090

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1199861

SETMR
Histone-lysine N-methyltransferase SETMAR

1

1

High-throughput

0.536

High

1357903

TOP1M
DNA topoisomerase I, mitochondrial

1

1

High-throughput

0.536

High

1357909

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1357913

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

5

High-throughput

0.536

High

1357924

RUVB2
RuvB-like 2

1

5

High-throughput

0.536

High

1115850

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.518

High

50920

SYCE3
Synaptonemal complex central element protein 3

1

0

High-throughput

0.513

High

155332

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

335482

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

478128

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.513

High

480240

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

574389

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

732656

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

775221

FUS
RNA-binding protein FUS

1

0

High-throughput

0.513

High

973993

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

976119

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1016355

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

1144100

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1160220

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.513

High

1217597

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.513

High

1280992

PXK
PX domain-containing protein kinase-like protein

1

0

High-throughput

0.513

High

1357912

AGO4
Protein argonaute-4

1

0

High-throughput

0.513

High

1357914

ANLN
Anillin

1

0

High-throughput

0.513

High

1357923

COG5
Conserved oligomeric Golgi complex subunit 5

1

0

High-throughput

0.513

High

1042897

ERCC6
DNA excision repair protein ERCC-6

1

8

High-throughput

0.501

High

764916

CTNB1
Catenin beta-1

1

0

Small-scale

0.493

High

1042036

LMNB2
Lamin-B2

1

1

High-throughput

0.489

High

1357905

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

173137

XPO1
Exportin-1

1

3

High-throughput

0.479

High

191018

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

260213

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

409012

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

414294

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

487572

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

674265

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

883629

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

970836

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

980046

H4
Histone H4

1

3

High-throughput

0.479

High

998591

H31
Histone H3.1

1

2

Small-scale

0.479

High

1037292

H11
Histone H1.1

1

2

Small-scale

0.479

High

1053707

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

1

Small-scale

0.479

High

1067539

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1132855

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

1139780

SETB1
Histone-lysine N-methyltransferase SETDB1

1

2

Small-scale

0.479

High

1194240

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

1338865

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1357904

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

3

Small-scale

0.479

High

1357908

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

1357910

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1357920

DNM3B
DNA

1

1

Small-scale

0.479

High

1357921

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1357922

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1357926

DNM3A
DNA

1

1

Small-scale

0.479

High

141020

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

559431

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.458

High

606939

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

800006

COIL
Coilin

1

0

High-throughput

0.458

High

935931

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.458

High

948511

ELOF1
Transcription elongation factor 1 homolog

1

0

Small-scale

0.458

High

995166

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1045571

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1138434

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1147218

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1357901

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1357906

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1357907

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1357915

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1357916

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1357917

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1357925

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

625524

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.445

High

884372

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

3

Small-scale

0.445

High

990977

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

3

Small-scale

0.445

High

1292790

SKAP1
Src kinase-associated phosphoprotein 1

1

1

High-throughput

0.445

High

302911

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

High-throughput

0.437

High

412324

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

995720

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

1254812

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1357900

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.437

High

316415

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.426

High

584125

FOSL2
Fos-related antigen 2

1

0

High-throughput

0.426

High

1056878

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

1357918

VSX1
Visual system homeobox 1

1

0

High-throughput

0.426

High

131071

TULP2
Tubby-related protein 2

2

0

High-throughput

0.328

High

217278

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.279

Low

884174

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

1315178

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

1331825

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

387993

FIBG
Fibrinogen gamma chain

1

0

Small-scale

0.249

Low

417625

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

829478

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

1160701

DREB
Drebrin

1

0

High-throughput

0.249

Low

1357919

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025