HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: SIN3A (Q96ST3)
Paired amphipathic helix protein Sin3a (Histone deacetylase complex subunit Sin3a) (Transcriptional corepressor Sin3a)
Gene: SIN3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 25314079, 12724404, 12398767, 9804427, 24981860, 16254079, 12453419, 18059533, 17827154, 12943729, 12493763, 9150134, 12091390, 35271311, 33283408, 14749338, 9885572, 12082111, 22493095, 21258344 and 2 others

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Identification Methods affinity chromatography technology, pull down, anti bait coimmunoprecipitation, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
and 12 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 488
Hs

1 1273
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm
+ Sp
+ Ce
+ Ce
+ Sp
+ Dm
+ Dm
+ Hs
+ At
+ Hs
+ At
+ Sc
+ Sc
+ Dm
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024