Protein: HEMH
Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)

Gene: HEMH, FECH
Organism: Homo sapiens
Interactions: 125
UniProt ID: P22830

Gene Ontology (top 5):
GO:0004325 - ferrochelatase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix
GO:0006091 - generation of precursor metabolites and energy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

611984

HEMH
Ferrochelatase, mitochondrial

3

1

Small-scale

0.857

High

611999

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

5

2

High-throughput

0.722

High

611987

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

5

0

High-throughput

0.690

High

612000

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

2

High-throughput

0.678

High

252803

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

2

2

Small-scale

0.655

High

123500

PGRC1
Membrane-associated progesterone receptor component 1

3

0

Small-scale

0.643

High

499531

CH60
60 kDa heat shock protein, mitochondrial

3

0

High-throughput

0.638

High

612019

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

398429

CP1A2
Cytochrome P450 1A2

2

0

High-throughput

0.602

High

612017

PDK2
[Pyruvate dehydrogenase

2

0

High-throughput

0.602

High

612031

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.602

High

612044

FMC1
Protein FMC1 homolog

2

0

High-throughput

0.602

High

612048

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

2

0

High-throughput

0.602

High

226536

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

612064

TMOD3
Tropomodulin-3

2

1

High-throughput

0.574

High

612066

TMOD4
Tropomodulin-4

2

1

High-throughput

0.574

High

262708

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

612060

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

1

1

Small-scale

0.536

High

611985

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

612023

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

258661

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

439779

NEP
Neprilysin

1

0

Small-scale

0.513

High

611992

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

612018

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

612027

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.513

High

612028

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

612042

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

612043

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

612061

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

0

High-throughput

0.513

High

612062

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.513

High

612068

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

612071

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

612073

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

612078

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

612008

NR1H3
Oxysterols receptor LXR-alpha

1

1

High-throughput

0.489

High

612022

FAH2B
Fumarylacetoacetate hydrolase domain-containing protein 2B

1

1

High-throughput

0.489

High

612032

UBL4B
Ubiquitin-like protein 4B

1

1

High-throughput

0.489

High

377097

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

612007

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

612034

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

612038

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

612041

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

612046

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

612050

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

612054

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

612063

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

258407

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

327357

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

440344

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

486459

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

488574

ARAF
Serine/threonine-protein kinase A-Raf

1

0

High-throughput

0.458

High

611990

BASI
Basigin

1

0

High-throughput

0.458

High

611994

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

612002

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

612004

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

612005

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

612006

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

612013

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

612014

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

612020

MIC10
MICOS complex subunit MIC10

1

0

Small-scale

0.458

High

612040

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

612047

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

612051

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

612052

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

612067

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

612069

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

612079

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

612009

ERCC8
DNA excision repair protein ERCC-8

1

1

Small-scale

0.437

High

612036

PHIP
PH-interacting protein

1

1

High-throughput

0.437

High

612055

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

612075

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.437

High

612016

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

483901

CALM1
Calmodulin-1

1

3

High-throughput

0.407

High

483974

CALM2
Calmodulin-2

1

3

High-throughput

0.407

High

484059

CALM3
Calmodulin-3

1

3

High-throughput

0.407

High

611997

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

554803

TIMP2
Metalloproteinase inhibitor 2

3

0

High-throughput

0.347

High

256620

CLU
Clustered mitochondria protein homolog

2

0

High-throughput

0.328

High

307242

RCBT2
RCC1 and BTB domain-containing protein 2

2

0

High-throughput

0.328

High

577725

NELFE
Negative elongation factor E

2

0

High-throughput

0.328

High

612029

NELFD
Negative elongation factor C/D

2

0

High-throughput

0.328

High

612037

NELFB
Negative elongation factor B

2

0

High-throughput

0.328

High

612059

MMP26
Matrix metalloproteinase-26

2

0

High-throughput

0.328

High

612012

CUL3
Cullin-3

2

0

High-throughput

0.318

High

612026

TRI74
Tripartite motif-containing protein 74

2

0

High-throughput

0.318

High

612010

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.282

High

64049

AQ12B
Aquaporin-12B

1

0

High-throughput

0.279

Low

147699

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.279

Low

257913

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.279

Low

315969

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

570621

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.279

Low

611988

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

0

High-throughput

0.279

Low

611991

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

612011

ROCK1
Rho-associated protein kinase 1

1

0

High-throughput

0.279

Low

612015

SRC8
Src substrate cortactin

1

0

High-throughput

0.279

Low

612025

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

612030

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.279

Low

612033

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.279

Low

612039

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.279

Low

612045

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

612072

TSP50
Probable threonine protease PRSS50

1

0

High-throughput

0.279

Low

612057

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

0

High-throughput

0.269

Low

612077

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

High-throughput

0.269

Low

450718

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.249

Low

551954

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

611986

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

611989

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

611993

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

611995

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.249

Low

611996

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

611998

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

612001

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

612003

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.249

Low

612021

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

612024

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

612035

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

612053

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

612056

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

612058

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

612065

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

612070

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

612074

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

Small-scale

0.249

Low

612076

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

0

High-throughput

0.249

Low

612049

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024