HitPredict

Interactor 1: NELL1 (Q92832)
Protein kinase C-binding protein NELL1 (NEL-like protein 1) (Nel-related protein 1)
Gene: NELL1

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF_CA~FXa_inhibition
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 810 Hs			1 273
+	Hs
		1303473 NELL2_HUMAN (6-807): 3.09e-99: 328: 55.24		EGFL7_HUMAN (1-273): 1.56e-39: 140: 100.00
+	Hs
		1271529 NELL1_HUMAN (1-810): 3.43e-108: 352: 100.00		NELL2_HUMAN (82-176): 2.46e-26: 109: 34.65
+	Hs
		596152 CO5A1_HUMAN (31-232): 9.57e-54: 204: 23.33		TENA_HUMAN (2-259): 1.79e-25: 107: 15.97
+	Mm
		1143214 NOTC3_MOUSE (155-809): 4.64e-29: 127: 13.13		EGFL7_MOUSE (1-272): 1.11e-36: 133: 78.10
+	Hs
		126398 MATN2_HUMAN (438-799): 1.34e-36: 150: 22.67		NELL1_HUMAN (82-180): 1.86e-26: 110: 36.63
+	Hs
		126401 MATN2_HUMAN (438-799): 1.34e-36: 150: 22.67		NELL2_HUMAN (82-176): 2.46e-26: 109: 34.65
+	Hs
		624332 TENA_HUMAN (202-748): 4.4e-49: 190: 16.43		NID2_HUMAN (4-190): 1.14e-09: 60.6: 14.49
+	Hs
		804379 JAG2_HUMAN (336-808): 1.18e-36: 151: 20.17		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		126382 MATN2_HUMAN (438-799): 1.34e-36: 150: 22.67		NID2_HUMAN (4-190): 1.14e-09: 60.6: 14.49
+	Rn
		250561 CUBN_RAT (152-526): 8.46e-26: 117: 13.58		CUBN_RAT (129-268): 1.23e-11: 66.8: 13.16
+	Ss
		94581 CUBN_PIG (202-515): 7.15e-19: 94.7: 11.04		CUBN_PIG (106-268): 1.19e-18: 87.6: 21.93
+	Hs
		537515 FBLN2_HUMAN (401-627): 5.26e-20: 97.8: 32.05		NID1_HUMAN (60-238): 6.36e-16: 79.5: 17.59
+	Hs
		804198 JAG1_HUMAN (171-575): 8.57e-24: 110: 12.96		NOTC1_HUMAN (80-168): 1.88e-09: 60.1: 21.81
+	Hs
		1059111 LTBP2_HUMAN (265-692): 1.3e-22: 106: 20.12		FBLN5_HUMAN (13-187): 8.52e-09: 57.5: 17.46
+	Dm
		90684 NOTCH_DROME (439-810): 1.43e-16: 87: 16.05		E1JHA6_DROME (2-138): 3.95e-12: 68.3: 13.61
+	Hs
		823113 AGRE5_HUMAN (382-508): 2.04e-19: 95.5: 34.07		AGRE2_HUMAN (17-109): 7.55e-09: 58.3: 16.35
+	Dm
		422709 NOTCH_DROME (439-810): 1.43e-16: 87: 16.05		NOTCH_DROME (68-172): 9.27e-10: 61: 22.32
+	Dm
		422713 NOTCH_DROME (439-810): 1.43e-16: 87: 16.05		DL_DROME (53-168): 1.69e-09: 60.1: 25.58