HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: CSN3 (Q9UNS2)
COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)
Gene: COPS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	31253590, 21145461, 19295130
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 423
+	Hs
		1042844 CUL3_HUMAN (8-780): 0: 754: 22.96		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1041281 CUL1_HUMAN (11-780): 0: 748: 27.84		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		1043308 CUL4A_HUMAN (16-780): 0: 744: 24.48		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Mm
		56786 CUL4B_MOUSE (16-780): 0: 736: 25.26		CSN3_MOUSE (1-423): 9.97e-145: 420: 99.53
+	Hs
		1043639 CUL4B_HUMAN (16-780): 0: 736: 25.39		CSN3_HUMAN (1-423): 2.33e-144: 419: 100.00
+	Hs
		897289 CUL5_HUMAN (1-780): 0: 792: 100.00		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Zm
		26321 A0A1D6J2B8_MAIZE (8-780): 0: 702: 23.20		A0A3L6E9W8_MAIZE (4-422): 4.55e-120: 359: 36.46
+	Hs
		198618 CUL3_HUMAN (8-780): 0: 754: 22.96		PSMD3_HUMAN (49-415): 3.19e-93: 292: 18.14
+	Hs
		897244 CUL3_HUMAN (8-780): 0: 754: 22.96		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	At
		1258869 CUL3A_ARATH (16-780): 0: 759: 23.18		CSN2_ARATH (19-398): 6.77e-85: 267: 11.95
+	Hs
		897242 CUL1_HUMAN (11-780): 0: 748: 27.84		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Mm
		897343 CUL1_MOUSE (11-780): 0: 748: 27.84		CSN2_MOUSE (21-393): 1.28e-87: 275: 12.23
+	Hs
		897245 CUL4A_HUMAN (16-780): 0: 744: 24.48		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		897246 CUL4B_HUMAN (16-780): 0: 736: 25.39		CSN2_HUMAN (21-393): 1.28e-87: 275: 12.23
+	Hs
		1274036 CUL5_HUMAN (1-780): 0: 792: 100.00		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	At
		1258866 CUL1_ARATH (8-780): 0: 721: 24.34		CSN2_ARATH (19-398): 6.77e-85: 267: 11.95
+	Hs
		1042418 CUL3_HUMAN (8-780): 0: 754: 22.96		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1041179 CUL1_HUMAN (11-780): 0: 748: 27.84		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1043195 CUL4A_HUMAN (16-780): 0: 744: 24.48		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87
+	Hs
		1043547 CUL4B_HUMAN (16-780): 0: 736: 25.39		CSN4_HUMAN (1-397): 3.04e-62: 208: 15.87