Protein: MOT1
Monocarboxylate transporter 1 (MCT 1) (Solute carrier family 16 member 1)

Gene: MOT1, SLC16A1
Organism: Homo sapiens
Interactions: 218
UniProt ID: P53985

Gene Ontology (top 5):
GO:0005813 - centrosome
GO:0005886 - plasma membrane
GO:0006629 - lipid metabolic process
GO:0007098 - centrosome cycle
GO:0008028 - monocarboxylic acid transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925555

EMB
Embigin

2

20

High-throughput

0.776

High

774229

BASI
Basigin

6

19

Small-scale

0.724

High

375320

RASK
GTPase KRas

4

16

High-throughput

0.676

High

373856

RASN
GTPase NRas

3

17

High-throughput

0.656

High

374497

RASH
GTPase HRas

3

15

High-throughput

0.640

High

925507

RHOA
Transforming protein RhoA

3

20

High-throughput

0.633

High

845569

MUC18
Cell surface glycoprotein MUC18

1

8

High-throughput

0.618

High

241184

PRKN
E3 ubiquitin-protein ligase parkin

3

3

High-throughput

0.585

High

925513

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

925571

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.575

High

436635

KPCB
Protein kinase C beta type

2

1

High-throughput

0.571

High

925559

TBA1A
Tubulin alpha-1A chain

2

7

High-throughput

0.571

High

925585

SNX27
Sorting nexin-27

2

7

High-throughput

0.571

High

925593

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

403936

GCR
Glucocorticoid receptor

2

0

Small-scale

0.547

High

925582

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

925589

CRBN
Protein cereblon

1

0

Small-scale

0.537

High

125722

STXB3
Syntaxin-binding protein 3

1

3

High-throughput

0.536

High

470271

NEP
Neprilysin

1

1

Small-scale

0.536

High

539786

RALA
Ras-related protein Ral-A

1

16

High-throughput

0.536

High

563471

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.536

High

698517

CALX
Calnexin

1

3

High-throughput

0.536

High

716003

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

7

High-throughput

0.536

High

925512

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.536

High

925519

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

925521

STX4
Syntaxin-4

1

2

High-throughput

0.536

High

925524

ILK
Scaffold protein ILK

1

4

High-throughput

0.536

High

925530

CUL3
Cullin-3

1

4

High-throughput

0.536

High

925533

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

High-throughput

0.536

High

925541

VAMP3
Vesicle-associated membrane protein 3

1

3

High-throughput

0.536

High

371553

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

720655

AGTR1
Type-1 angiotensin II receptor

1

0

High-throughput

0.518

High

925509

AP1S1
AP-1 complex subunit sigma-1A

1

1

High-throughput

0.515

High

925625

THS7A
Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]

1

5

High-throughput

0.515

High

925622

SWP70
Switch-associated protein 70

1

2

High-throughput

0.515

High

571126

CD99
CD99 antigen

1

0

High-throughput

0.513

High

773834

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

925515

GBG5

1

0

High-throughput

0.513

High

178621

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.493

High

341920

CEP43
Centrosomal protein 43

1

0

High-throughput

0.493

High

642746

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.493

High

925527

SERC3
Serine incorporator 3

1

0

High-throughput

0.493

High

925523

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.489

High

925529

CUL2
Cullin-2

1

4

High-throughput

0.489

High

925542

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.489

High

925563

ST32C
Serine/threonine-protein kinase 32C

1

2

High-throughput

0.489

High

925573

COQ8A
Atypical kinase COQ8A, mitochondrial

1

5

High-throughput

0.489

High

925590

DNJC2
DnaJ homolog subfamily C member 2

1

7

High-throughput

0.489

High

126520

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

157132

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

178223

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

189477

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

217998

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

315323

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

325749

UBR5
E3 ubiquitin-protein ligase UBR5

1

9

High-throughput

0.479

High

342803

HERC2
E3 ubiquitin-protein ligase HERC2

1

9

High-throughput

0.479

High

345560

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

349014

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

411640

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

420446

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

10

High-throughput

0.479

High

463416

LYN
Tyrosine-protein kinase Lyn

1

7

High-throughput

0.479

High

466170

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

482593

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

6

High-throughput

0.479

High

925588

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

534824

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

540374

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

565837

EF2
Elongation factor 2

1

1

High-throughput

0.479

High

580951

RAC2
Ras-related C3 botulinum toxin substrate 2

1

18

High-throughput

0.479

High

591253

CD44
CD44 antigen

1

3

Small-scale

0.479

High

598045

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

11

High-throughput

0.479

High

601220

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

715501

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

766346

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

830403

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

861082

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

861944

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

897177

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

900742

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

904494

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

909988

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

925504

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

925505

RAB2A
Ras-related protein Rab-2A

1

8

High-throughput

0.479

High

925508

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

4

High-throughput

0.479

High

925511

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

925514

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

925517

LAT1
Large neutral amino acids transporter small subunit 1

1

10

High-throughput

0.479

High

925518

1433F
14-3-3 protein eta

1

8

High-throughput

0.479

High

925526

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

925537

RAB35
Ras-related protein Rab-35

1

7

High-throughput

0.479

High

925540

T22D1
TSC22 domain family protein 1

1

1

High-throughput

0.479

High

925546

PKHG4
Puratrophin-1

1

2

High-throughput

0.479

High

925553

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

925560

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

925561

CNTRL
Centriolin

1

2

High-throughput

0.479

High

925570

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

925578

ARRD3
Arrestin domain-containing protein 3

1

4

Small-scale

0.479

High

925602

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

925604

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

925605

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

925610

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

925615

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

925620

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

925621

SEC63
Translocation protein SEC63 homolog

1

7

High-throughput

0.479

High

925624

ALK
ALK tyrosine kinase receptor

1

3

Small-scale

0.479

High

925629

HBS1L
HBS1-like protein

1

2

High-throughput

0.479

High

925630

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

925632

SRPRB
Signal recognition particle receptor subunit beta

1

6

High-throughput

0.479

High

925577

DPF1
Zinc finger protein neuro-d4

1

1

High-throughput

0.470

High

319560

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

349890

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

413467

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

618670

ML12A
Myosin regulatory light chain 12A

1

0

High-throughput

0.458

High

799814

COIL
Coilin

1

0

High-throughput

0.458

High

925499

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

925503

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

925520

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.458

High

925534

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.458

High

925539

KS6A1
Ribosomal protein S6 kinase alpha-1

1

0

High-throughput

0.458

High

925556

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

925569

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

925576

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

925587

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

925592

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

418630

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

7

High-throughput

0.445

High

421779

A4
Amyloid-beta precursor protein

1

8

Small-scale

0.445

High

925501

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

925502

CD81
CD81 antigen

1

4

High-throughput

0.445

High

925535

GOGB1
Golgin subfamily B member 1

1

2

High-throughput

0.445

High

925538

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.445

High

925598

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

925612

TM9S3
Transmembrane 9 superfamily member 3

1

6

High-throughput

0.445

High

925616

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

2

High-throughput

0.445

High

925626

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

925627

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.445

High

105629

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

125348

LEG9
Galectin-9

1

4

High-throughput

0.437

High

137686

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.437

High

184827

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.437

High

246493

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.437

High

293417

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

405936

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

588290

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

883189

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.437

High

907345

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

925522

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

925525

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

925528

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.437

High

925532

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.437

High

925536

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

925544

MIDN
Midnolin

1

1

High-throughput

0.437

High

925545

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

5

High-throughput

0.437

High

925552

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

925558

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

925564

ZCH18
Zinc finger CCCH domain-containing protein 18

1

2

High-throughput

0.437

High

925581

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.437

High

925586

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

14

High-throughput

0.437

High

925595

TRI55
Tripartite motif-containing protein 55

1

5

High-throughput

0.437

High

925596

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.437

High

925599

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.437

High

925603

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.437

High

925607

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

925608

BRD9
Bromodomain-containing protein 9

1

5

High-throughput

0.437

High

925613

BRD7
Bromodomain-containing protein 7

1

5

High-throughput

0.437

High

925618

TECR
Very-long-chain enoyl-CoA reductase

1

3

High-throughput

0.437

High

925623

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

925628

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

925631

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

3

High-throughput

0.437

High

278836

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.426

High

896224

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.426

High

925548

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

925617

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

143

A0A024R6X4
PLEKHG4

1

2

High-throughput

0.407

High

890106

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.407

High

925567

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

925600

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.407

High

925584

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

925606

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

925609

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4

1

0

High-throughput

0.279

Low

925550

GARL3
GTPase-activating Rap/Ran-GAP domain-like protein 3

1

0

High-throughput

0.269

Low

925572

NGDN
Neuroguidin

1

0

High-throughput

0.269

Low

925551

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.268

Low

986

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.253

Low

50853

NDUF8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

1

0

High-throughput

0.249

Low

274998

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.249

Low

283829

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

470940

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.249

Low

505424

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

551735

COBA1

1

0

High-throughput

0.249

Low

695017

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

767779

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

878829

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

925500

SUMO3
Small ubiquitin-related modifier 3

1

0

High-throughput

0.249

Low

925506

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.249

Low

925510

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

925516

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

925531

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

925543

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

925547

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

925549

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

925554

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.249

Low

925557

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

925562

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.249

Low

925565

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.249

Low

925566

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

925568

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

925574

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.249

Low

925575

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.249

Low

925579

PF21A
PHD finger protein 21A

1

0

High-throughput

0.249

Low

925583

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

925591

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

925594

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

925597

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.249

Low

925601

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

925611

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low

925614

ANLN
Anillin

1

0

High-throughput

0.249

Low

925619

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.249

Low

925633

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.249

Low

925580

OTUL
Ubiquitin thioesterase otulin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025