HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: TARA (Q9H2D6)
TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)
Gene: TRIOBP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2365
+	Hs
		564677 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		TARA_HUMAN (1-2365): 4.78e-172: 589: 100.00
+	Hs
		892586 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		TARA_HUMAN (1-2365): 4.78e-172: 589: 100.00
+	Hs
		951324 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		TARA_HUMAN (1-2365): 4.78e-172: 589: 100.00
+	Hs
		254468 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		254445 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		254512 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		254462 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		254472 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ROCK2_HUMAN (1806-2363): 5.22e-37: 156: 12.52
+	Hs
		724757 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		724776 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		725138 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH10_HUMAN (1444-2225): 5.59e-28: 126: 9.89
+	Hs
		725125 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MYH10_HUMAN (1444-2225): 5.59e-28: 126: 9.89
+	Ce
		136793 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		UNC89_CAEEL (392-957): 7.22e-20: 100: 14.04
+	Hs
		297823 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		K0754_HUMAN (38-333): 3.28e-10: 68.4: 18.18
+	Hs
		551652 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		DESP_HUMAN (1531-2365): 6.57e-16: 86.9: 10.21
+	Hs
		925204 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Hs
		297812 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		K0754_HUMAN (38-333): 3.28e-10: 68.4: 18.18
+	Hs
		297840 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		K0754_HUMAN (38-333): 3.28e-10: 68.4: 18.18
+	Hs
		297819 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		K0754_HUMAN (38-333): 3.28e-10: 68.4: 18.18
+	Hs
		297827 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		K0754_HUMAN (38-333): 3.28e-10: 68.4: 18.18