HitPredict

Interactor 1: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23275444
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2177 Hs			1 870
+	Hs
		1085631 MED12_HUMAN (1-2177): 0: 2488: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1270775 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1244293 ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20		EPAS1_HUMAN (1-870): 0: 863: 100.00
+	Hs
		1085623 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Rn
		193481 CBP_RAT (1658-2026): 7.81e-09: 63.4: 11.32		HIF1A_RAT (3-787): 0: 555: 43.98
+	Mm
		70923 EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10		HIF1A_MOUSE (3-787): 0: 549: 43.60
+	Hs
		1085646 EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Mm
		70944 EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10		BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91
+	Mm
		799605 CBP_MOUSE (1658-2031): 7.06e-10: 66.9: 11.66		BMAL1_MOUSE (1-524): 1.34e-131: 409: 20.91
+	Hs
		126156 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		BMAL1_HUMAN (1-524): 1.58e-129: 403: 20.70
+	Hs
		181549 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		CLOCK_HUMAN (3-780): 7.98e-123: 393: 17.42
+	Mm
		101411 F8VPR5_MOUSE (1658-2031): 7.3e-10: 66.9: 11.66		CLOCK_MOUSE (3-672): 1.48e-120: 387: 18.59
+	Ce
		108089 UNC89_CAEEL (1599-2149): 1.94e-20: 101: 10.83		HIF1_CAEEL (5-671): 6.8e-105: 342: 18.21
+	Mm
		70918 EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10		BMAL2_MOUSE (16-475): 5.6e-113: 359: 22.11
+	Mm
		799600 CBP_MOUSE (1658-2031): 7.06e-10: 66.9: 11.66		BMAL2_MOUSE (16-475): 5.6e-113: 359: 22.11
+	Hs
		1270854 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47
+	Hs
		1075384 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		NCOA2_HUMAN (6-564): 4.76e-97: 334: 18.53
+	Hs
		1057760 NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91		NCOA2_HUMAN (6-564): 4.76e-97: 334: 18.53
+	Hs
		1270774 CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45		NPAS2_HUMAN (1-770): 5.24e-96: 321: 17.18