Protein: MED26
Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)

Gene: MED26
Organism: Homo sapiens
Interactions: 118
UniProt ID: O95402

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335986

MED21
Mediator of RNA polymerase II transcription subunit 21

8

0

Small-scale

0.924

High

219463

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.921

High

336032

MED4
Mediator of RNA polymerase II transcription subunit 4

8

1

Small-scale

0.754

High

335993

MED1
Mediator of RNA polymerase II transcription subunit 1

6

1

Small-scale

0.738

High

48887

MED19
Mediator of RNA polymerase II transcription subunit 19

10

0

Small-scale

0.722

High

335978

RPB7
DNA-directed RNA polymerase II subunit RPB7

8

0

High-throughput

0.720

High

239514

MED14
Mediator of RNA polymerase II transcription subunit 14

5

2

Small-scale

0.718

High

335967

CDK8
Cyclin-dependent kinase 8

5

1

Small-scale

0.716

High

336033

MED17
Mediator of RNA polymerase II transcription subunit 17

5

1

High-throughput

0.716

High

336026

MED10
Mediator of RNA polymerase II transcription subunit 10

7

0

Small-scale

0.716

High

336027

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

High-throughput

0.707

High

336029

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

High-throughput

0.705

High

336034

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.701

High

336016

MED12
Mediator of RNA polymerase II transcription subunit 12

4

1

Small-scale

0.694

High

336023

MED15
Mediator of RNA polymerase II transcription subunit 15

4

1

Small-scale

0.694

High

336039

MED13
Mediator of RNA polymerase II transcription subunit 13

4

1

Small-scale

0.694

High

336035

MED29
Mediator of RNA polymerase II transcription subunit 29

5

0

High-throughput

0.691

High

336028

CDK19
Cyclin-dependent kinase 19

4

1

Small-scale

0.691

High

335973

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

5

0

High-throughput

0.686

High

336044

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

High-throughput

0.674

High

336004

MED27
Mediator of RNA polymerase II transcription subunit 27

4

0

High-throughput

0.670

High

336030

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

High-throughput

0.670

High

336036

MED11
Mediator of RNA polymerase II transcription subunit 11

4

0

High-throughput

0.670

High

287748

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

High-throughput

0.667

High

335963

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

1

High-throughput

0.667

High

335988

MED22
Mediator of RNA polymerase II transcription subunit 22

3

1

High-throughput

0.667

High

336006

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

3

1

High-throughput

0.667

High

335952

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

High-throughput

0.664

High

192770

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.646

High

335953

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

0

High-throughput

0.646

High

336041

MED23
Mediator of RNA polymerase II transcription subunit 23

3

0

High-throughput

0.646

High

282336

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

335958

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.638

High

335961

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

0

High-throughput

0.638

High

335972

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

0

High-throughput

0.638

High

335979

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

0

High-throughput

0.638

High

336007

MED25
Mediator of RNA polymerase II transcription subunit 25

3

0

Small-scale

0.638

High

336018

MED8
Mediator of RNA polymerase II transcription subunit 8

3

0

High-throughput

0.638

High

336020

MED30
Mediator of RNA polymerase II transcription subunit 30

3

0

High-throughput

0.638

High

336043

MED16
Mediator of RNA polymerase II transcription subunit 16

3

0

High-throughput

0.638

High

335956

TCEA1
Transcription elongation factor A protein 1

1

1

High-throughput

0.618

High

335987

ELOA1
Elongin-A

1

1

High-throughput

0.618

High

335964

SRBP1
Sterol regulatory element-binding protein 1

3

0

Small-scale

0.613

High

335957

CCNC
Cyclin-C

2

2

High-throughput

0.611

High

335977

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.602

High

137306

ELL2
RNA polymerase II elongation factor ELL2

2

3

High-throughput

0.601

High

336038

AFF4
AF4/FMR2 family member 4

2

2

High-throughput

0.601

High

259256

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

142468

IMA3
Importin subunit alpha-3

2

0

High-throughput

0.576

High

336010

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.547

High

335948

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.546

High

130681

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.536

High

251491

CCNT1
Cyclin-T1

1

2

High-throughput

0.536

High

252227

CCNT2
Cyclin-T2

1

2

High-throughput

0.536

High

335955

TAF1
Transcription initiation factor TFIID subunit 1

1

1

High-throughput

0.536

High

335966

AF9
Protein AF-9

1

2

High-throughput

0.536

High

335969

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.536

High

335975

ELL
RNA polymerase II elongation factor ELL

1

2

High-throughput

0.536

High

336000

TAF3
Transcription initiation factor TFIID subunit 3

1

1

High-throughput

0.536

High

336008

TAF8
Transcription initiation factor TFIID subunit 8

1

1

High-throughput

0.536

High

336013

TAF4B
Transcription initiation factor TFIID subunit 4B

1

1

High-throughput

0.536

High

336014

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.536

High

336017

EAF2
ELL-associated factor 2

1

1

High-throughput

0.536

High

336021

EAF1
ELL-associated factor 1

1

1

High-throughput

0.536

High

335954

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

335968

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

335974

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

335984

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.513

High

335989

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.513

High

335990

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.513

High

335991

TAF11
Transcription initiation factor TFIID subunit 11

1

0

High-throughput

0.513

High

335992

TAF7
Transcription initiation factor TFIID subunit 7

1

0

High-throughput

0.513

High

335995

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

336001

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

336003

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.513

High

336019

GWL
Serine/threonine-protein kinase greatwall

1

0

High-throughput

0.513

High

336042

ICE1
Little elongation complex subunit 1

1

0

High-throughput

0.513

High

335970

AFF1
AF4/FMR2 family member 1

1

2

High-throughput

0.489

High

169870

AURKA
Aurora kinase A

1

0

Small-scale

0.480

High

336046

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

283411

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

335959

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.479

High

335982

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

335983

ENL
Protein ENL

1

1

High-throughput

0.479

High

336009

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

1

High-throughput

0.479

High

336022

QKI
KH domain-containing RNA-binding protein QKI

1

1

High-throughput

0.479

High

262464

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

326278

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

335951

CEBPB
CCAAT/enhancer-binding protein beta

1

0

Small-scale

0.458

High

335960

PML
Protein PML

1

0

High-throughput

0.458

High

335981

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

335985

SMAD4
Mothers against decapentaplegic homolog 4

1

0

Small-scale

0.458

High

335998

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

335999

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

336005

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

336015

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

336024

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

336031

ELL3
RNA polymerase II elongation factor ELL3

1

2

High-throughput

0.445

High

316237

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.426

High

325634

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.426

High

335962

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

335965

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

0

High-throughput

0.426

High

335971

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.426

High

335996

SMN
Survival motor neuron protein

1

0

High-throughput

0.426

High

335997

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

336012

TITIN
Titin

1

0

High-throughput

0.426

High

336037

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.426

High

336045

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

335950

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.288

High

335994

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.279

Low

336011

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

336002

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

335949

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.232

Low

335976

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.232

Low

335980

DCD
Dermcidin

1

0

High-throughput

0.232

Low

336025

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.232

Low

336040

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025