HitPredict

Interactor 1: WBP2 (Q969T9)
WW domain-binding protein 2 (WBP-2)
Gene: WBP2

Interactor 2: NED4L (Q96PU5)
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
Gene: NEDD4L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	27182664, 27578003, 19953087
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 975
+	Mm
		808347 WBP2_MOUSE (1-261): 1.95e-70: 218: 96.94		NEDD4_MOUSE (12-975): 0: 794: 55.19
+	Hs
		1282381 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		WWP1_HUMAN (1-972): 0: 781: 33.13
+	Hs
		1282371 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		ITCH_HUMAN (9-972): 0: 772: 33.16
+	Hs
		808210 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		NEDD4_HUMAN (94-975): 0: 724: 49.78
+	Hs
		125630 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		WWP2_HUMAN (228-972): 0: 719: 37.80
+	Hs
		1192157 WBP2_HUMAN (1-261): 1.74e-72: 224: 100.00		HUWE1_HUMAN (358-973): 3.88e-170: 554: 32.26
+	Ce
		1090426 Q18966_CAEEL (1-231): 7.38e-52: 170: 32.64		WWP1_CAEEL (16-344): 8.43e-11: 68: 16.50