Protein: SYF1
Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)

Gene: SYF1, XAB2
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q9HCS7

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0001824 - blastocyst development
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1439441

PPIE
Peptidyl-prolyl cis-trans isomerase E

9

8

High-throughput

0.759

High

1439439

ISY1
Pre-mRNA-splicing factor ISY1 homolog

5

6

High-throughput

0.722

High

1128120

DHX8
ATP-dependent RNA helicase DHX8

5

19

High-throughput

0.712

High

485738

RU2A
U2 small nuclear ribonucleoprotein A'

4

10

Small-scale

0.696

High

1439445

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

4

2

High-throughput

0.694

High

1412030

WDR83
WD repeat domain-containing protein 83

4

20

High-throughput

0.691

High

974053

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.675

High

1439440

PRP19
Pre-mRNA-processing factor 19

3

20

High-throughput

0.675

High

1286223

RALYL
RNA-binding Raly-like protein

3

20

High-throughput

0.667

High

1410076

USB1
U6 snRNA phosphodiesterase 1

3

1

High-throughput

0.667

High

1415990

YJU2
Splicing factor YJU2

3

6

High-throughput

0.667

High

351359

SYF2
Pre-mRNA-splicing factor SYF2

3

1

High-throughput

0.662

High

1111283

SNW1
SNW domain-containing protein 1

2

8

High-throughput

0.644

High

373211

MYC
Myc proto-oncogene protein

3

12

High-throughput

0.640

High

1404424

CDC5L
Cell division cycle 5-like protein

3

13

High-throughput

0.636

High

222535

PLRG1
Pleiotropic regulator 1

2

20

High-throughput

0.628

High

574482

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

11

High-throughput

0.628

High

973828

RUXE
Small nuclear ribonucleoprotein E

2

5

High-throughput

0.628

High

991256

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

13

High-throughput

0.628

High

1432359

PININ
Pinin

2

3

High-throughput

0.628

High

245158

AQR
RNA helicase aquarius

2

2

Small-scale

0.619

High

974203

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

1127177

RBM39
RNA-binding protein 39

2

17

High-throughput

0.611

High

1387577

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

20

High-throughput

0.611

High

1290745

ZCH18
Zinc finger CCCH domain-containing protein 18

3

9

High-throughput

0.609

High

298086

SPF27
Pre-mRNA-splicing factor SPF27

2

3

High-throughput

0.601

High

569275

YJU2B
Probable splicing factor YJU2B

2

6

High-throughput

0.601

High

667467

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

6

Small-scale

0.601

High

129449

MEN1
Menin

2

8

High-throughput

0.584

High

905166

MECP2
Methyl-CpG-binding protein 2

2

5

High-throughput

0.584

High

1241803

PRP8
Pre-mRNA-processing-splicing factor 8

2

10

High-throughput

0.584

High

1098377

ERCC8
DNA excision repair protein ERCC-8

1

20

Small-scale

0.578

High

1090303

ELAV2
ELAV-like protein 2

2

12

High-throughput

0.574

High

1256739

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

1371449

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.574

High

1383602

K1143
Uncharacterized protein KIAA1143

2

2

High-throughput

0.574

High

1439428

DJC17
DnaJ homolog subfamily C member 17

2

13

High-throughput

0.574

High

238955

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

17

High-throughput

0.573

High

1095184

RED
Protein Red

1

2

High-throughput

0.573

High

1105420

SF3B2
Splicing factor 3B subunit 2

1

3

High-throughput

0.573

High

396992

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1398934

ZN830
Zinc finger protein 830

2

0

Small-scale

0.559

High

1419618

GLIS2
Zinc finger protein GLIS2

1

4

Small-scale

0.541

High

74614

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

18

High-throughput

0.536

High

192646

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

256688

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

18

High-throughput

0.536

High

273003

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

462655

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.536

High

471929

RU2B
U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.536

High

478216

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.536

High

480314

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

542231

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.536

High

807591

IF4A3
Eukaryotic initiation factor 4A-III

1

12

High-throughput

0.536

High

974850

SMD3
Small nuclear ribonucleoprotein Sm D3

1

19

High-throughput

0.536

High

1016627

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

1042929

ERCC6
DNA excision repair protein ERCC-6

1

15

Small-scale

0.536

High

1089566

ILF2
Interleukin enhancer-binding factor 2

1

7

High-throughput

0.536

High

1099552

SRSF6
Serine/arginine-rich splicing factor 6

1

15

High-throughput

0.536

High

1114360

CUL3
Cullin-3

1

13

High-throughput

0.536

High

1138658

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

14

High-throughput

0.536

High

1145387

RNPS1
RNA-binding protein with serine-rich domain 1

1

20

High-throughput

0.536

High

1149197

SF3A1
Splicing factor 3A subunit 1

1

7

High-throughput

0.536

High

1160095

SRSF7
Serine/arginine-rich splicing factor 7

1

15

High-throughput

0.536

High

1160308

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

14

High-throughput

0.536

High

1168899

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

7

High-throughput

0.536

High

1252526

LN28B
Protein lin-28 homolog B

1

8

High-throughput

0.536

High

1356572

CCD12
Coiled-coil domain-containing protein 12

1

3

High-throughput

0.536

High

1361527

CTBL1
Beta-catenin-like protein 1

1

1

High-throughput

0.536

High

1383863

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1387274

HDA11
Histone deacetylase 11

1

6

High-throughput

0.536

High

1387899

PABP5
Polyadenylate-binding protein 5

1

7

High-throughput

0.536

High

1439434

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1439436

HSPB8
Heat shock protein beta-8

1

5

High-throughput

0.536

High

1439437

RALY
RNA-binding protein Raly

1

13

High-throughput

0.536

High

1439444

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

4

High-throughput

0.536

High

654136

XPA
DNA repair protein complementing XP-A cells

1

0

Small-scale

0.529

High

1137534

SUZ12
Polycomb protein SUZ12

1

4

High-throughput

0.515

High

844006

HD
Huntingtin

1

3

High-throughput

0.515

High

326163

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.513

High

1234622

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

1439432

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

1089885

ILF3
Interleukin enhancer-binding factor 3

1

16

High-throughput

0.508

High

964464

SUMO2
Small ubiquitin-related modifier 2

1

9

High-throughput

0.501

High

813225

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.493

High

347350

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

1348966

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

1369535

KIFA3
Kinesin-associated protein 3

1

9

High-throughput

0.489

High

1439442

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

1

High-throughput

0.489

High

1439443

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.489

High

134874

SAP18
Histone deacetylase complex subunit SAP18

1

2

High-throughput

0.479

High

157879

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.479

High

242999

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

260484

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

283552

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

346366

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.479

High

401523

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

414670

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

473103

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

16

High-throughput

0.479

High

485433

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

11

Small-scale

0.479

High

520387

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

558424

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

589753

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

607123

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

696572

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

714440

PML
Protein PML

1

11

High-throughput

0.479

High

769240

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

775324

FUS
RNA-binding protein FUS

1

18

High-throughput

0.479

High

879491

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

881610

CDK8
Cyclin-dependent kinase 8

1

5

High-throughput

0.479

High

942902

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.479

High

961111

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

971113

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

980367

H4
Histone H4

1

5

High-throughput

0.479

High

995829

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.479

High

1024858

VIGLN
Vigilin

1

12

High-throughput

0.479

High

1067735

EP300
Histone acetyltransferase p300

1

8

High-throughput

0.479

High

1094632

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.479

High

1132990

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.479

High

1156865

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

1161686

IF16
Gamma-interferon-inducible protein 16

1

8

High-throughput

0.479

High

1201285

EAPP
E2F-associated phosphoprotein

1

2

High-throughput

0.479

High

1229695

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1235531

IFIX
Pyrin and HIN domain-containing protein 1

1

8

High-throughput

0.479

High

1276819

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

1289641

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1313447

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1314430

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.479

High

1346939

SNIP1
Smad nuclear-interacting protein 1

1

4

High-throughput

0.479

High

1352765

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1367335

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368895

RBP56
TATA-binding protein-associated factor 2N

1

11

High-throughput

0.479

High

1382846

FUBP1
Far upstream element-binding protein 1

1

12

High-throughput

0.479

High

1404776

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1407889

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

1417481

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1431319

ATG5
Autophagy protein 5

1

4

High-throughput

0.479

High

1433780

SENP3
Sentrin-specific protease 3

1

5

Small-scale

0.479

High

1439426

ANLN
Anillin

1

6

High-throughput

0.479

High

1439427

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1439429

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1439430

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1439431

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

1439433

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1439438

NUP50
Nuclear pore complex protein Nup50

1

2

High-throughput

0.479

High

1314550

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

71619

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

638528

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.445

High

896458

ERF
ETS domain-containing transcription factor ERF

1

10

High-throughput

0.445

High

1130467

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

10

High-throughput

0.445

High

1198668

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

1203266

ODFP2
Outer dense fiber protein 2

1

4

High-throughput

0.445

High

1439435

DDX41
Probable ATP-dependent RNA helicase DDX41

1

12

High-throughput

0.445

High

272475

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.437

High

412645

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

1215845

RC3H1
Roquin-1

1

6

High-throughput

0.437

High

1255636

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1393717

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.437

High

1433950

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1210996

CE170
Centrosomal protein of 170 kDa

1

6

High-throughput

0.407

High

1366251

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.407

High

1439446

NPTN
Neuroplastin

1

4

High-throughput

0.407

High

591374

CD44
CD44 antigen

2

0

High-throughput

0.328

High

269063

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

0

High-throughput

0.269

Low

85311

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

Small-scale

0.249

Low

1258078

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

640294

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.238

Low

947058

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

1218168

CAHD1
VWFA and cache domain-containing protein 1

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025