HitPredict

Interactor 1: TLK2 (Q86UE8)
Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)
Gene: TLK2

Interactor 2: DYL2 (Q96FJ2)
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)
Gene: DYNLL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	27173435, 33961781, 35271311, 32707033, unassigned3799
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 89
+	Hs
		991598 TLK2_HUMAN (1-754): 0: 594: 100.00		DYL1_HUMAN (1-89): 1.81e-47: 147: 93.26
+	Hs
		991760 TLK1_HUMAN (2-769): 1.62e-144: 444: 65.46		DYL1_HUMAN (1-89): 1.81e-47: 147: 93.26
+	Hs
		1390747 TLK1_HUMAN (2-769): 1.62e-144: 444: 65.46		DYL2_HUMAN (1-89): 7.12e-47: 146: 100.00
+	Hs
		1390760 MAST1_HUMAN (85-770): 2.88e-119: 394: 18.03		DYL2_HUMAN (1-89): 7.12e-47: 146: 100.00
+	Hs
		605633 KAPCA_HUMAN (450-772): 3.35e-126: 382: 23.78		DYL1_HUMAN (1-89): 1.81e-47: 147: 93.26
+	Hs
		605778 KAPCA_HUMAN (450-772): 3.35e-126: 382: 23.78		DYL2_HUMAN (1-89): 7.12e-47: 146: 100.00
+	Hs
		354856 KCC2D_HUMAN (457-743): 3.46e-106: 335: 28.57		DNAL4_HUMAN (7-89): 8.2e-30: 103: 32.94
+	Dm
		84963 B7Z126_DROME (201-352): 2.24e-46: 181: 40.13		DYL1_DROME (1-89): 7.59e-48: 148: 96.63