Protein: TLK2
Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)

Gene: TLK2
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q86UE8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1288393

TLK1
Serine/threonine-protein kinase tousled-like 1

7

17

Small-scale

0.967

High

987093

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

11

High-throughput

0.811

High

1288342

TLK2
Serine/threonine-protein kinase tousled-like 2

2

16

High-throughput

0.783

High

242160

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

1288396

ASF1A
Histone chaperone ASF1A

8

6

Small-scale

0.754

High

1288383

ASF1B
Histone chaperone ASF1B

8

6

Small-scale

0.752

High

991598

DYL1
Dynein light chain 1, cytoplasmic

7

8

Small-scale

0.748

High

170218

AURKA
Aurora kinase A

1

16

Small-scale

0.724

High

1288360

DYL2
Dynein light chain 2, cytoplasmic

5

8

High-throughput

0.716

High

135262

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

11

High-throughput

0.691

High

171270

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

11

High-throughput

0.691

High

691784

MK03
Mitogen-activated protein kinase 3

1

20

High-throughput

0.691

High

1148354

KS6A1
Ribosomal protein S6 kinase alpha-1

1

17

High-throughput

0.691

High

1178770

AAK1
AP2-associated protein kinase 1

1

19

High-throughput

0.691

High

1288358

DOC10
Dedicator of cytokinesis protein 10

1

6

High-throughput

0.691

High

1288362

GWL
Serine/threonine-protein kinase greatwall

1

19

High-throughput

0.691

High

1288366

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

11

High-throughput

0.691

High

1288384

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

8

High-throughput

0.691

High

290392

RFPL3
Ret finger protein-like 3

3

10

High-throughput

0.667

High

1288346

EID3
EP300-interacting inhibitor of differentiation 3

3

1

High-throughput

0.667

High

1288395

LHX6
LIM/homeobox protein Lhx6

3

7

High-throughput

0.667

High

1288399

CABIN
Calcineurin-binding protein cabin-1

3

3

High-throughput

0.667

High

276375

LIPA2
Liprin-alpha-2

1

12

High-throughput

0.618

High

1088153

CNTN1
Contactin-1

1

1

High-throughput

0.618

High

1090249

ELAV2
ELAV-like protein 2

1

11

High-throughput

0.618

High

1249935

ISLR2
Immunoglobulin superfamily containing leucine-rich repeat protein 2

1

4

High-throughput

0.618

High

1288368

LRFN5
Leucine-rich repeat and fibronectin type-III domain-containing protein 5

1

3

High-throughput

0.618

High

412186

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.618

High

1288394

SCML1
Sex comb on midleg-like protein 1

1

1

High-throughput

0.618

High

926673

HIRA
Protein HIRA

2

8

High-throughput

0.611

High

685252

PAX6
Paired box protein Pax-6

2

8

High-throughput

0.606

High

1037728

PAX5
Paired box protein Pax-5

2

7

High-throughput

0.606

High

1288363

GMCL1
Germ cell-less protein-like 1

2

8

High-throughput

0.606

High

1145817

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.586

High

1288355

IRF7
Interferon regulatory factor 7

1

3

High-throughput

0.586

High

1288380

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

1219187

SPAT1
Spermatogenesis-associated protein 1

2

1

High-throughput

0.574

High

1288350

CEP70
Centrosomal protein of 70 kDa

2

1

High-throughput

0.553

High

1288367

FRMD6
FERM domain-containing protein 6

2

11

High-throughput

0.553

High

1288347

RHG24
Rho GTPase-activating protein 24

1

8

High-throughput

0.553

High

1288385

CALL5
Calmodulin-like protein 5

1

16

High-throughput

0.553

High

128450

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

2

High-throughput

0.536

High

244169

KIF5C
Kinesin heavy chain isoform 5C

1

3

High-throughput

0.536

High

425819

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

6

High-throughput

0.536

High

425924

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.536

High

455816

H10
Histone H1.0

1

1

High-throughput

0.536

High

551135

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.536

High

566180

K1C10
Keratin, type I cytoskeletal 10

1

12

High-throughput

0.536

High

566416

K2C5
Keratin, type II cytoskeletal 5

1

2

High-throughput

0.536

High

669934

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.536

High

772026

K1C9
Keratin, type I cytoskeletal 9

1

13

High-throughput

0.536

High

775442

DDIT3
DNA damage-inducible transcript 3 protein

1

1

High-throughput

0.536

High

788089

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

841816

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.536

High

845326

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

14

High-throughput

0.536

High

863417

GLYG
Glycogenin-1

1

1

High-throughput

0.536

High

1035412

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.536

High

1121811

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

13

High-throughput

0.536

High

1219084

DAB2P
Disabled homolog 2-interacting protein

1

11

High-throughput

0.536

High

1278680

KI21A
Kinesin-like protein KIF21A

1

2

High-throughput

0.536

High

1288351

SMRC2
SWI/SNF complex subunit SMARCC2

1

5

High-throughput

0.536

High

1288364

ABHEB
Putative protein-lysine deacylase ABHD14B

1

1

High-throughput

0.536

High

1288365

ZFR
Zinc finger RNA-binding protein

1

3

High-throughput

0.536

High

1288369

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

8

High-throughput

0.536

High

1288372

BTBDA
BTB/POZ domain-containing protein 10

1

5

High-throughput

0.536

High

1288374

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.536

High

1288376

DDX24
ATP-dependent RNA helicase DDX24

1

8

High-throughput

0.536

High

1288377

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.536

High

1288382

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

4

High-throughput

0.536

High

1288388

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

2

High-throughput

0.536

High

1270697

Q7KZS0
SUMO-conjugating enzyme UBC9

1

9

High-throughput

0.515

High

2140

KVD13
Immunoglobulin kappa variable 1D-13

1

1

High-throughput

0.514

High

378733

KVD33
Immunoglobulin kappa variable 1D-33

1

1

High-throughput

0.514

High

484585

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1212410

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.513

High

1231250

REP15
Rab15 effector protein

1

0

High-throughput

0.513

High

1288356

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.513

High

1288357

UPP
Uracil phosphoribosyltransferase homolog

1

0

High-throughput

0.513

High

1288389

COE1
Transcription factor COE1

1

0

High-throughput

0.513

High

164375

NRP1
Neuropilin-1

1

1

High-throughput

0.489

High

520902

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.489

High

522455

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.489

High

568569

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.489

High

884153

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.489

High

1006202

CNTP1
Contactin-associated protein 1

1

2

High-throughput

0.489

High

1060537

KLC1
Kinesin light chain 1

1

2

High-throughput

0.489

High

1112436

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

7

High-throughput

0.489

High

1216300

MTCL3
Microtubule cross-linking factor 3

1

20

High-throughput

0.489

High

1288348

NLGN1
Neuroligin-1

1

3

High-throughput

0.489

High

1288349

RN214
RING finger protein 214

1

5

High-throughput

0.489

High

1288353

DLG3
Disks large homolog 3

1

7

High-throughput

0.489

High

1288354

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

2

High-throughput

0.489

High

1288361

CHMP6
Charged multivesicular body protein 6

1

4

High-throughput

0.489

High

1288371

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.489

High

1288375

PDGFD
Platelet-derived growth factor D

1

3

High-throughput

0.489

High

1288398

SHLB1
Endophilin-B1

1

4

High-throughput

0.489

High

993637

UBC9
SUMO-conjugating enzyme UBC9

1

9

High-throughput

0.481

High

279408

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

348593

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

370328

CYTA
Cystatin-A

1

2

High-throughput

0.479

High

372452

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

589054

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

695844

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

714235

PML
Protein PML

1

13

High-throughput

0.479

High

881068

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

887000

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

888165

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

998492

H31
Histone H3.1

1

17

High-throughput

0.479

High

1068844

IFFO1
Non-homologous end joining factor IFFO1

1

10

High-throughput

0.479

High

1097393

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1106348

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

11

High-throughput

0.479

High

1138360

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1158899

RBBP7
Histone-binding protein RBBP7

1

9

High-throughput

0.479

High

1217144

RIF1
Telomere-associated protein RIF1

1

4

High-throughput

0.479

High

1256475

UBN2
Ubinuclein-2

1

4

High-throughput

0.479

High

1276427

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1288345

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1288352

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1288359

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.479

High

1288379

S10AE
Protein S100-A14

1

10

High-throughput

0.479

High

1288381

UBN1
Ubinuclein-1

1

1

High-throughput

0.479

High

168282

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

1030468

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1288343

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

1288373

CDAC1
Cytidine and dCMP deaminase domain-containing protein 1

1

0

High-throughput

0.458

High

1288386

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.458

High

1288397

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.458

High

537438

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.445

High

1288378

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.445

High

1288387

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

4

Small-scale

0.445

High

1288370

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.439

High

1288391

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.439

High

346014

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.437

High

649739

SPR1B
Cornifin-B

1

1

High-throughput

0.437

High

942721

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.437

High

1200459

COBL1
Cordon-bleu protein-like 1

1

4

High-throughput

0.437

High

1288344

AMOL1
Angiomotin-like protein 1

1

14

High-throughput

0.437

High

1288392

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.437

High

347143

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.407

High

1288390

IL36A
Interleukin-36 alpha

2

0

High-throughput

0.328

High

568665

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.279

Low

848043

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.279

Low

903982

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.279

Low

1142448

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.279

Low

1209032

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

1254204

PPR3F
Protein phosphatase 1 regulatory subunit 3F

1

0

High-throughput

0.279

Low

1279269

SPT19
Spermatogenesis-associated protein 19, mitochondrial

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025