HitPredict

Interactor 1: PABP5 (Q96DU9)
Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5)
Gene: PABPC5

Interactor 2: SRSF8 (Q9BRL6)
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Gene: SRSF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 282
+	Hs
		1020306 PABP5_HUMAN (1-382): 2.22e-103: 311: 100.00		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516635 PABP5_HUMAN (1-382): 2.22e-103: 311: 100.00		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		1119141 PABP5_HUMAN (1-382): 2.22e-103: 311: 100.00		PAP1L_HUMAN (2-103): 2.9e-20: 92.1: 22.55
+	Mm
		857332 TIA1_MOUSE (194-379): 5.58e-49: 171: 23.40		SRSF2_MOUSE (1-100): 1.3e-41: 144: 80.00
+	Zm
		8143 A0A1D6ELH4_MAIZE (108-381): 1.16e-57: 200: 31.05		A0A1D6ELH4_MAIZE (12-99): 5.87e-17: 82.5: 20.46
+	Mm
		665745 TIA1_MOUSE (194-379): 5.58e-49: 171: 23.40		PABP1_MOUSE (2-103): 2.27e-20: 92.5: 18.63
+	Hs
		474019 PAB4L_HUMAN (198-380): 1.64e-41: 151: 26.63		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		474021 PAB4L_HUMAN (198-380): 1.64e-41: 151: 26.63		PABP4_HUMAN (2-103): 9.14e-22: 96.7: 19.61
+	Hs
		582231 NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11		SRSF2_HUMAN (1-100): 1.3e-41: 144: 80.00
+	Hs
		516689 PABP3_HUMAN (19-201): 3.02e-32: 129: 28.64		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		582561 NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11		PPIE_HUMAN (16-102): 3.36e-32: 122: 35.63
+	Sc
		376562 PABP_YEAST (1-198): 1.85e-28: 118: 22.79		PABP_YEAST (2-103): 2.06e-20: 92.5: 19.61
+	Sc
		376694 PABP_YEAST (1-198): 1.85e-28: 118: 22.79		PUB1_YEAST (12-99): 1.78e-17: 83.7: 20.46
+	Hs
		1020249 PABP4_HUMAN (5-199): 1.19e-17: 86.6: 15.74		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516355 NUCL_HUMAN (4-96): 1.1e-19: 92.8: 30.11		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516484 PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60		ELAV2_HUMAN (2-99): 7.35e-24: 100: 22.45
+	Hs
		516495 PABP4_HUMAN (5-199): 1.19e-17: 86.6: 15.74		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516339 PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60		PABP1_HUMAN (2-103): 1.99e-20: 92.9: 18.63
+	Hs
		516471 PABP1_HUMAN (292-378): 3.47e-17: 85.1: 23.60		TIAR_HUMAN (8-102): 5.22e-19: 87.5: 26.32