HitPredict

Interactor 1: RNF31 (Q96EP0)
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
Gene: RNF31

Interactor 2: UBE2T (Q9NPD8)
Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)
Gene: UBE2T

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	30017913
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E3_UbLigase_RBR~UQ_con, IBR~UQ_con
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1072 Hs			1 197
+	Hs
		1290106 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2D4_HUMAN (2-152): 1.11e-77: 230: 39.74
+	Hs
		849403 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		919819 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2D2_HUMAN (2-152): 1.52e-76: 227: 41.72
+	Hs
		895873 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		1290028 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2E2_HUMAN (3-152): 6.78e-69: 210: 40.00
+	Hs
		1282324 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2E3_HUMAN (3-152): 1.45e-68: 209: 40.00
+	Hs
		851865 RNF31_HUMAN (1-1072): 0: 1111: 100.00		UB2E1_HUMAN (3-152): 1.27e-67: 206: 40.00
+	Mm
		895978 RNF31_MOUSE (1-1072): 0: 1083: 85.54		UB2D3_MOUSE (2-152): 2.48e-75: 224: 41.06
+	Hs
		849498 ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		895968 ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		896576 ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84		UBE2N_HUMAN (4-152): 1.1e-70: 213: 44.97
+	Hs
		1297383 ARI1_HUMAN (600-1058): 1.52e-114: 367: 13.84		UB2E2_HUMAN (3-152): 6.78e-69: 210: 40.00
+	Hs
		312520 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2D1_HUMAN (2-152): 1.05e-76: 228: 41.72
+	Hs
		312553 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2D2_HUMAN (2-152): 1.52e-76: 227: 41.72
+	Sc
		549808 HEL1_YEAST (621-1042): 5.5e-90: 301: 14.92		UBC4_YEAST (1-151): 3.03e-76: 227: 41.72
+	Hs
		312528 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2D3_HUMAN (2-152): 2.48e-75: 224: 41.06
+	Hs
		312529 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UBE2N_HUMAN (4-152): 1.1e-70: 213: 44.97
+	Hs
		312645 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2E2_HUMAN (3-152): 6.78e-69: 210: 40.00
+	Hs
		312639 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2E3_HUMAN (3-152): 1.45e-68: 209: 40.00
+	Hs
		312522 ARI2_HUMAN (654-1044): 9.03e-91: 301: 15.84		UB2E1_HUMAN (3-152): 1.27e-67: 206: 40.00