HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27872092
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 970 Hs			1 1025
+	Hs
		861804 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Bt
		1100183 ROCK2_BOVIN (5-783): 4.62e-144: 465: 16.02		ROCK2_BOVIN (492-990): 3.23e-14: 79.7: 13.69
+	Hs
		724810 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		254476 ROCK1_HUMAN (5-620): 1.38e-134: 439: 19.42		ROCK2_HUMAN (446-1018): 6.09e-17: 88.7: 11.81
+	Hs
		861924 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		1255120 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		160627 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		1292228 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		149166 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		724962 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		522653 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (101-931): 7.33e-17: 88.6: 10.36
+	Hs
		725220 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH10_HUMAN (534-1014): 3.94e-16: 85.9: 9.18
+	Hs
		522582 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (122-873): 2.75e-15: 83.2: 8.13
+	Hs
		728527 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		728503 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		1068636 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		1189785 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89