HitPredict

Interactor 1: PLK4 (O00444)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)
Gene: PLK4

Interactor 2: LZTS2 (Q9BRK4)
Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
Gene: LZTS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24613305
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 970 Hs			1 669
+	Hs
		129015 PLK4_HUMAN (1-970): 0: 1040: 100.00		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		129013 PLK4_HUMAN (1-970): 0: 1040: 100.00		MRCKA_HUMAN (328-609): 6.79e-09: 61.6: 11.68
+	Dm
		332684 PLK4_DROME (6-662): 7.98e-125: 399: 32.09		Q960T6_DROME (305-647): 1.85e-11: 69.6: 17.90
+	Hs
		160453 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		SMCA4_HUMAN (18-526): 1.58e-30: 130: 13.06
+	Hs
		861770 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		ITSN1_HUMAN (75-640): 4.07e-22: 104: 13.88
+	Hs
		1268102 PLK2_HUMAN (15-264): 1.56e-59: 218: 41.60		MY18A_HUMAN (329-637): 1.72e-11: 70: 17.67
+	Hs
		861751 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		861960 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90
+	Hs
		160561 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		861795 PLK1_HUMAN (17-266): 1.34e-54: 202: 37.60		CP135_HUMAN (300-610): 1.6e-09: 63.5: 21.52
+	Hs
		160824 AURKA_HUMAN (9-273): 3.28e-53: 193: 37.74		EP15R_HUMAN (483-668): 6.69e-11: 67.8: 12.90
+	Hs
		522582 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH1_HUMAN (152-661): 8.43e-14: 77.4: 8.93
+	Hs
		1357872 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH4_HUMAN (261-669): 1.55e-12: 73.1: 12.32
+	Hs
		1051404 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		DCTN1_HUMAN (88-572): 2.4e-12: 72.7: 10.41
+	Hs
		728527 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH11_HUMAN (141-564): 3.93e-11: 68.9: 11.53
+	Hs
		728503 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH11_HUMAN (141-564): 3.93e-11: 68.9: 11.53
+	Hs
		528433 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH8_HUMAN (196-572): 6.41e-09: 61.6: 9.26
+	Hs
		522653 AURKC_HUMAN (9-269): 1.49e-50: 182: 34.87		MYH7_HUMAN (140-540): 9.01e-09: 61.2: 9.45
+	Hs
		149166 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		CTRO_HUMAN (327-578): 7.02e-09: 61.3: 16.36
+	Hs
		725220 AURKB_HUMAN (9-269): 1.34e-49: 181: 36.78		MYH10_HUMAN (321-640): 8.77e-09: 61.2: 18.79