Protein: SRCAP
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)

Gene: SRCAP
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q6ZRS2

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0000812 - Swr1 complex
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1253885

RUVB2
RuvB-like 2

7

20

High-throughput

0.960

High

1253886

RUVB1
RuvB-like 1

6

20

High-throughput

0.943

High

502025

H2AZ
Histone H2A.Z

5

20

Small-scale

0.919

High

1253863

H2B1A
Histone H2B type 1-A

4

20

High-throughput

0.892

High

1253875

DMAP1
DNA methyltransferase 1-associated protein 1

4

7

Small-scale

0.892

High

1253868

ARP6
Actin-related protein 6

3

20

High-throughput

0.861

High

980867

H2B1C
Histone H2B type 1-C/E/F/G/I

3

20

High-throughput

0.827

High

1200982

ACTBL
Beta-actin-like protein 2

2

20

High-throughput

0.811

High

979867

H4
Histone H4

2

15

High-throughput

0.754

High

998466

H31
Histone H3.1

2

20

High-throughput

0.754

High

340352

YETS4
YEATS domain-containing protein 4

4

11

High-throughput

0.699

High

952913

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.691

High

993223

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.691

High

1163005

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

1253851

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.691

High

211650

ZNHI1
Zinc finger HIT domain-containing protein 1

4

2

Small-scale

0.678

High

1253888

CARD8
Caspase recruitment domain-containing protein 8

3

1

High-throughput

0.667

High

995656

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

1253854

NF2IP
NFATC2-interacting protein

2

2

High-throughput

0.628

High

1253860

CBP
CREB-binding protein

2

20

Small-scale

0.620

High

754883

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

1016971

H33
Histone H3.3

1

20

High-throughput

0.618

High

1253855

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1253880

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

15

High-throughput

0.618

High

1253846

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

4

High-throughput

0.604

High

1099710

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

4

High-throughput

0.601

High

372369

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

1067448

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

1155298

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

4

Small-scale

0.575

High

1253844

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

391308

FRIL
Ferritin light chain

2

1

High-throughput

0.549

High

278372

NCOR1
Nuclear receptor corepressor 1

1

20

Small-scale

0.536

High

542081

TOP1
DNA topoisomerase 1

1

8

High-throughput

0.536

High

601739

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

High-throughput

0.536

High

649344

H1T
Histone H1t

1

8

High-throughput

0.536

High

1013075

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

3

High-throughput

0.536

High

1031916

NC2B
Protein Dr1

1

4

High-throughput

0.536

High

1134620

NUMA1
Nuclear mitotic apparatus protein 1

1

12

High-throughput

0.536

High

1253850

RN168
E3 ubiquitin-protein ligase RNF168

1

5

High-throughput

0.536

High

1253867

NUF2
Kinetochore protein Nuf2

1

3

High-throughput

0.536

High

1253871

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

3

High-throughput

0.536

High

1253889

NGN3
Neurogenin-3

1

12

High-throughput

0.536

High

1253848

CARM1
Histone-arginine methyltransferase CARM1

1

7

Small-scale

0.527

High

862242

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.515

High

666854

CCNC
Cyclin-C

1

2

High-throughput

0.515

High

1142579

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.513

High

1253890

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.513

High

964340

SUMO2
Small ubiquitin-related modifier 2

1

14

High-throughput

0.501

High

1244614

GASP3
G protein-coupled receptor associated sorting protein 3

1

0

High-throughput

0.493

High

1253857

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.493

High

1253873

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.493

High

1253884

SRTD3
SERTA domain-containing protein 3

1

0

High-throughput

0.493

High

1253849

INLR1
Interferon lambda receptor 1

1

1

High-throughput

0.489

High

1253858

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

1

High-throughput

0.489

High

1253859

DI3L1
DIS3-like exonuclease 1

1

3

High-throughput

0.489

High

129201

MEN1
Menin

1

6

High-throughput

0.479

High

180852

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.479

High

190967

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

11

High-throughput

0.479

High

242067

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

272274

OBSL1
Obscurin-like protein 1

1

6

High-throughput

0.479

High

414071

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

487453

PARP1
Poly [ADP-ribose] polymerase 1

1

18

High-throughput

0.479

High

520149

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

577454

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

588983

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

675555

TYY1
Transcriptional repressor protein YY1

1

11

High-throughput

0.479

High

685242

PAX6
Paired box protein Pax-6

1

8

High-throughput

0.479

High

695769

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

13

High-throughput

0.479

High

697153

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

High-throughput

0.479

High

738998

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

768490

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

833976

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

904857

MECP2
Methyl-CpG-binding protein 2

1

20

High-throughput

0.479

High

1113479

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1133484

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1136799

MO4L2
Mortality factor 4-like protein 2

1

3

Small-scale

0.479

High

1152702

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1253845

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1253847

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1253852

SIR6
NAD-dependent protein deacylase sirtuin-6

1

13

High-throughput

0.479

High

1253861

KAT5
Histone acetyltransferase KAT5

1

9

Small-scale

0.479

High

1253865

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1253869

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1253870

WWTR1
WW domain-containing transcription regulator protein 1

1

17

High-throughput

0.479

High

1253876

ANLN
Anillin

1

4

High-throughput

0.479

High

1253877

MRGBP
MRG/MORF4L-binding protein

1

2

Small-scale

0.479

High

1253878

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1253881

MO4L1
Mortality factor 4-like protein 1

1

3

Small-scale

0.479

High

1253882

CFDP1
Craniofacial development protein 1

1

1

High-throughput

0.479

High

1253883

XPO7
Exportin-7

1

3

High-throughput

0.479

High

1253887

ASF1A
Histone chaperone ASF1A

1

11

High-throughput

0.479

High

684010

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

6

High-throughput

0.470

High

1253853

USBP1
Harmonin-binding protein USHBP1

1

5

High-throughput

0.470

High

1253866

TRI54
Tripartite motif-containing protein 54

1

12

High-throughput

0.470

High

1253891

X5D778
Ankyrin repeat domain 11 isoform A

1

5

High-throughput

0.470

High

791021

TALDO
Transaldolase

1

0

High-throughput

0.458

High

334565

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

11

Small-scale

0.457

High

430060

JUN
Transcription factor Jun

1

16

High-throughput

0.445

High

1196880

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

10

High-throughput

0.445

High

1199535

KLH22
Kelch-like protein 22

1

4

High-throughput

0.445

High

1253862

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

20

High-throughput

0.445

High

1253864

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

18

High-throughput

0.445

High

1253874

RAB18
Ras-related protein Rab-18

1

2

High-throughput

0.445

High

353405

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

1164434

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

1253872

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

1253879

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

58845

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

4

High-throughput

0.407

High

1144772

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

1253856

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025