HitPredict

Interactor 1: CERS2 (Q96G23)
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Sphingosine N-acyltransferase CERS2) (EC 2.3.1.24) (Tumor metastasis-suppressor gene 1 protein) (Very-long-chain ceramide synthase CERS2) (EC 2.3.1.297)
Gene: CERS2

Interactor 2: ELOV2 (Q9NXB9)
Very long chain fatty acid elongase 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Elongation of very long chain fatty acids protein 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3-oxoacyl-CoA synthase 2)
Gene: ELOVL2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20937905
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0030148 - sphingolipid biosynthetic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 296
+	Hs
		1291819 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV5_HUMAN (7-296): 5.76e-107: 314: 55.44
+	Hs
		1291800 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV4_HUMAN (22-296): 3.51e-97: 290: 44.77
+	Hs
		50787 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV7_HUMAN (5-262): 4.48e-81: 248: 40.60
+	Hs
		1291795 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV1_HUMAN (9-262): 7.99e-81: 247: 33.21
+	Hs
		1291806 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV6_HUMAN (30-268): 3.12e-50: 168: 23.08
+	Hs
		1291811 CERS2_HUMAN (1-380): 6.94e-161: 457: 100.00		ELOV3_HUMAN (30-267): 1.23e-49: 167: 25.10
+	Sc
		752766 LAG1_YEAST (116-356): 1.97e-68: 222: 24.31		ELO3_YEAST (50-257): 9.42e-38: 138: 23.58
+	Sc
		659164 LAC1_YEAST (116-337): 1.78e-60: 202: 20.76		ELO3_YEAST (50-257): 9.42e-38: 138: 23.58