HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1089
+	Hs
		129176 P85B_HUMAN (1-728): 0: 549: 100.00		PGFRB_HUMAN (29-1089): 0: 650: 43.33
+	Hs
		557215 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		PGFRA_HUMAN (1-1089): 0: 817: 100.00
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (18-994): 0: 571: 33.43
+	Hs
		129178 P85B_HUMAN (1-728): 0: 549: 100.00		KIT_HUMAN (18-978): 0: 559: 33.64
+	Hs
		499280 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		KIT_HUMAN (18-978): 0: 559: 33.64
+	Ce
		106190 G5EDP9_CAEEL (318-717): 1.77e-95: 307: 26.27		EGL15_CAEEL (5-1072): 3.56e-155: 490: 16.61
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (48-776): 2.93e-51: 197: 14.04
+	Hs
		129199 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR2_HUMAN (6-339): 9.02e-49: 189: 14.90
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (573-690): 7.85e-22: 104: 43.22
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (128-609): 7.49e-19: 94.9: 11.28
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (212-602): 7.71e-15: 81.4: 10.59
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (3-177): 1.39e-14: 80.7: 10.71
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (28-227): 3.23e-13: 76.1: 9.01
+	Hs
		1083875 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK2_HUMAN (48-776): 2.93e-51: 197: 14.04
+	Hs
		608065 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		FGFR4_HUMAN (3-221): 4.21e-22: 104: 8.36
+	Hs
		674489 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		UFO_HUMAN (13-225): 2.38e-15: 83.4: 14.71
+	Dm
		112231 SRC42_DROME (551-727): 1.47e-35: 143: 22.78		M9MRE1_DROME (20-534): 4.38e-44: 176: 17.11
+	Dm
		112209 ABL_DROME (531-725): 1.27e-32: 138: 20.92		M9MRE1_DROME (20-534): 4.38e-44: 176: 17.11