Protein: SYDC
Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)

Gene: SYDC, DARS1
Organism: Homo sapiens
Interactions: 202
UniProt ID: P14868

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004046 - aminoacylase activity
GO:0004815 - aspartate-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

576759

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

8

5

Small-scale

0.971

High

576771

SYK
Lysine--tRNA ligase

2

13

High-throughput

0.811

High

140132

SDCB1
Syntenin-1

3

1

High-throughput

0.667

High

576736

SYRC
Arginine--tRNA ligase, cytoplasmic

3

4

High-throughput

0.667

High

576840

SYLC
Leucine--tRNA ligase, cytoplasmic

3

14

High-throughput

0.667

High

563121

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.650

High

240652

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

345323

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

2

High-throughput

0.640

High

536423

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.633

High

576731

SYQ
Glutamine--tRNA ligase

2

14

High-throughput

0.628

High

576757

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

2

8

High-throughput

0.628

High

576727

SYIC
Isoleucine--tRNA ligase, cytoplasmic

2

11

Small-scale

0.611

High

576749

GRB2
Growth factor receptor-bound protein 2

2

1

High-throughput

0.611

High

576763

CUL3
Cullin-3

2

6

High-throughput

0.611

High

576798

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

1

High-throughput

0.611

High

395426

ESR1
Estrogen receptor

2

5

Small-scale

0.585

High

400229

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

High-throughput

0.584

High

576836

ANLN
Anillin

2

2

High-throughput

0.584

High

429235

JUN
Transcription factor Jun

1

4

High-throughput

0.554

High

576712

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.553

High

576720

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.553

High

576707

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

576724

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

215493

EMC8
ER membrane protein complex subunit 8

1

3

High-throughput

0.536

High

303401

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

361099

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

576722

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

576723

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

576730

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

576745

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

576750

RACK1
Small ribosomal subunit protein RACK1

1

7

High-throughput

0.536

High

576762

CUL1
Cullin-1

1

6

High-throughput

0.536

High

576765

CAPR1
Caprin-1

1

3

High-throughput

0.536

High

576768

CND2
Condensin complex subunit 2

1

1

High-throughput

0.536

High

576775

PKN2
Serine/threonine-protein kinase N2

1

2

High-throughput

0.536

High

576812

CUL5
Cullin-5

1

6

High-throughput

0.536

High

576822

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

4

High-throughput

0.536

High

576843

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.536

High

576850

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

576852

EMC9
ER membrane protein complex subunit 9

1

3

High-throughput

0.536

High

354894

CHK2
Serine/threonine-protein kinase Chk2

1

1

High-throughput

0.515

High

459215

CATL1
Procathepsin L

1

2

High-throughput

0.515

High

576726

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

135476

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

576709

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

576753

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

576808

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

3

High-throughput

0.508

High

576756

FOXM1
Forkhead box protein M1

1

2

High-throughput

0.506

High

576742

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

576752

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.501

High

576754

ERCC6
DNA excision repair protein ERCC-6

1

1

High-throughput

0.501

High

576809

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

484363

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

576785

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.489

High

576817

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

576824

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.489

High

128749

MEN1
Menin

1

1

High-throughput

0.479

High

131710

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

137942

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

High-throughput

0.479

High

156912

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

179811

BET1
BET1 homolog

1

1

High-throughput

0.479

High

213794

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.479

High

214169

MCA3
Eukaryotic translation elongation factor 1 epsilon-1

1

12

High-throughput

0.479

High

227349

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

293151

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

315082

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

319363

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

323151

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

324494

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

352314

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

375140

RASK
GTPase KRas

1

1

High-throughput

0.479

High

388986

FINC
Fibronectin

1

2

High-throughput

0.479

High

411293

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

425292

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

507488

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

565122

ITA4
Integrin alpha-4

1

4

High-throughput

0.479

High

576703

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

4

Small-scale

0.479

High

576706

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

576710

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

576711

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.479

High

576713

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.479

High

576714

UFO
Tyrosine-protein kinase receptor UFO

1

5

High-throughput

0.479

High

576716

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

576717

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

576718

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

576719

MERL
Merlin

1

2

High-throughput

0.479

High

576721

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

576725

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

576729

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

576732

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

576735

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

576737

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

576738

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

High-throughput

0.479

High

576746

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

576748

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

4

High-throughput

0.479

High

576758

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

576760

TIF1B
Transcription intermediary factor 1-beta

1

4

High-throughput

0.479

High

576761

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

576764

CUL4A
Cullin-4A

1

6

High-throughput

0.479

High

576769

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

576770

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

576772

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

576774

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.479

High

576776

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

576777

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

576780

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

576781

A16L1
Autophagy-related protein 16-1

1

7

High-throughput

0.479

High

576782

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

576783

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

576784

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

576786

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

576787

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

576790

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

576792

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.479

High

576793

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

576794

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

576796

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

576797

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

Small-scale

0.479

High

576801

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.479

High

576802

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

576803

FBX25
F-box only protein 25

1

1

High-throughput

0.479

High

576805

D42E1
Short-chain dehydrogenase/reductase family 42E member 1

1

1

High-throughput

0.479

High

576807

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

576811

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.479

High

576813

FBXW7
F-box/WD repeat-containing protein 7

1

5

High-throughput

0.479

High

576815

ARMC5
Armadillo repeat-containing protein 5

1

4

High-throughput

0.479

High

576816

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

576819

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

576820

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

576821

NECD
Necdin

1

1

High-throughput

0.479

High

576823

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

576825

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

576827

TRI31
E3 ubiquitin-protein ligase TRIM31

1

5

High-throughput

0.479

High

576833

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

576835

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

576837

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

576838

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

576839

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.479

High

576842

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

576844

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

High-throughput

0.479

High

576847

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

576848

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

576853

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

125201

LEG9
Galectin-9

1

0

High-throughput

0.458

High

349776

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

362694

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

466624

GLI1
Zinc finger protein GLI1

1

0

Small-scale

0.458

High

576708

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

576728

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

576741

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

576747

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

576751

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

576766

CUL7
Cullin-7

1

0

High-throughput

0.458

High

576767

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

576773

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

576778

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

576800

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

576804

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

576810

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

576826

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

576831

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

576845

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

461104

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.457

High

576739

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

576791

SDCG8
Serologically defined colon cancer antigen 8

1

4

Small-scale

0.445

High

576832

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

High-throughput

0.445

High

576849

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

533576

CLUS
Clusterin

1

0

High-throughput

0.438

High

105255

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

193971

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

276051

NIPS2
Protein NipSnap homolog 2

1

1

Small-scale

0.437

High

371067

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

451325

NFM
Neurofilament medium polypeptide

1

1

High-throughput

0.437

High

576704

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

576733

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

576743

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.437

High

576755

TLE2
Transducin-like enhancer protein 2

1

6

High-throughput

0.437

High

576788

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

576789

KCTD9
BTB/POZ domain-containing protein KCTD9

1

3

High-throughput

0.437

High

576806

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

576829

ASXL3
Putative Polycomb group protein ASXL3

1

3

High-throughput

0.437

High

576841

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

2

High-throughput

0.437

High

576846

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.437

High

346834

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

576744

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

576799

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

576828

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

576740

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

254782

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.407

High

576834

VIAAT
Vesicular inhibitory amino acid transporter

1

2

High-throughput

0.407

High

576734

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.373

High

576830

SPRTN
DNA-dependent metalloprotease SPRTN

2

0

Small-scale

0.305

High

576715

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

576818

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

576705

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

High-throughput

0.261

Low

239706

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

352921

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

576795

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

576814

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.249

Low

576851

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

913

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

576779

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025