HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 821
+	Hs
		129184 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR1_HUMAN (1-820): 0: 772: 71.17
+	Hs
		129201 P85B_HUMAN (1-728): 0: 549: 100.00		FGFR4_HUMAN (22-810): 0: 684: 55.86
+	Hs
		129209 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA3_HUMAN (18-778): 3.24e-168: 514: 18.30
+	Hs
		129211 P85B_HUMAN (1-728): 0: 549: 100.00		EPHB2_HUMAN (9-766): 1.95e-166: 511: 17.58
+	Hs
		129253 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA4_HUMAN (18-794): 4.37e-165: 506: 18.60
+	Hs
		129252 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA5_HUMAN (18-766): 3.48e-163: 502: 17.53
+	Hs
		129215 P85B_HUMAN (1-728): 0: 549: 100.00		UFO_HUMAN (5-818): 3.59e-160: 490: 22.49
+	Hs
		129299 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK3_HUMAN (166-765): 7.85e-160: 488: 25.31
+	Hs
		129297 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA7_HUMAN (64-791): 2.59e-157: 486: 19.23
+	Hs
		129208 P85B_HUMAN (1-728): 0: 549: 100.00		EPHA2_HUMAN (18-798): 4.64e-157: 485: 19.21
+	Mm
		140060 P85B_MOUSE (1-728): 0: 541: 88.87		UFO_MOUSE (4-818): 1.83e-159: 488: 22.46
+	Hs
		129300 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK2_HUMAN (123-765): 4.81e-153: 469: 23.43
+	Hs
		129170 P85B_HUMAN (1-728): 0: 549: 100.00		RET_HUMAN (228-816): 2.74e-144: 455: 34.26
+	Hs
		129160 P85B_HUMAN (1-728): 0: 549: 100.00		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Mm
		140055 P85B_MOUSE (1-728): 0: 541: 88.87		KIT_MOUSE (60-803): 1.29e-139: 439: 26.86
+	Hs
		129178 P85B_HUMAN (1-728): 0: 549: 100.00		KIT_HUMAN (60-803): 1.89e-130: 415: 25.23
+	Hs
		129165 P85B_HUMAN (1-728): 0: 549: 100.00		CSF1R_HUMAN (467-753): 1.87e-78: 275: 43.11
+	Hs
		385265 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04
+	Hs
		499280 P55G_HUMAN (312-722): 1.53e-103: 326: 71.85		KIT_HUMAN (60-803): 1.89e-130: 415: 25.23
+	Hs
		129225 P85B_HUMAN (1-728): 0: 549: 100.00		VGFR3_HUMAN (42-385): 5.85e-18: 91.4: 17.62