Protein: PRP4
U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)

Gene: PRP4, PRPF4
Organism: Homo sapiens
Interactions: 220
UniProt ID: O43172

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

209157

PPIH
Peptidyl-prolyl cis-trans isomerase H

8

7

Small-scale

0.970

High

209156

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

7

4

Small-scale

0.966

High

209174

PRP6
Pre-mRNA-processing factor 6

6

18

High-throughput

0.950

High

209318

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

5

16

High-throughput

0.932

High

209287

PRP8
Pre-mRNA-processing-splicing factor 8

5

5

High-throughput

0.927

High

209330

DDX23
Probable ATP-dependent RNA helicase DDX23

4

14

High-throughput

0.909

High

209227

NH2L1
NHP2-like protein 1

4

10

Small-scale

0.905

High

209171

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

2

20

High-throughput

0.811

High

209258

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

6

High-throughput

0.811

High

209282

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

2

15

High-throughput

0.811

High

209269

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.789

High

209359

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

8

Small-scale

0.789

High

209268

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

6

20

Small-scale

0.737

High

209308

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

5

10

Small-scale

0.723

High

209300

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

5

4

Small-scale

0.722

High

209361

LSM4
U6 snRNA-associated Sm-like protein LSm4

5

20

High-throughput

0.718

High

209180

LSM8
U6 snRNA-associated Sm-like protein LSm8

4

16

High-throughput

0.699

High

209237

LSM6
U6 snRNA-associated Sm-like protein LSm6

4

20

High-throughput

0.699

High

209335

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

4

3

High-throughput

0.697

High

209290

MEPCE
7SK snRNA methylphosphate capping enzyme

4

2

High-throughput

0.694

High

209224

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.691

High

209231

RS16
Small ribosomal subunit protein uS9

1

6

High-throughput

0.691

High

209263

DX39B
Spliceosome RNA helicase DDX39B

1

16

High-throughput

0.691

High

209273

SF3A1
Splicing factor 3A subunit 1

1

10

High-throughput

0.691

High

209319

TOE1
Target of EGR1 protein 1

1

1

High-throughput

0.691

High

209336

DHX33
ATP-dependent RNA helicase DHX33

1

12

High-throughput

0.691

High

209342

DDX21
Nucleolar RNA helicase 2

1

17

High-throughput

0.691

High

209234

RUXF
Small nuclear ribonucleoprotein F

3

20

High-throughput

0.675

High

209238

SMD2
Small nuclear ribonucleoprotein Sm D2

3

5

High-throughput

0.675

High

209261

PRP4K
Serine/threonine-protein kinase PRP4 homolog

3

20

High-throughput

0.675

High

209312

N42L2
NEDD4-binding protein 2-like 2

3

3

High-throughput

0.675

High

209155

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

3

6

Small-scale

0.667

High

209358

LSM2
U6 snRNA-associated Sm-like protein LSm2

3

20

High-throughput

0.667

High

209249

U2AF1
Splicing factor U2AF 35 kDa subunit

1

3

High-throughput

0.656

High

209170

WBP4
WW domain-binding protein 4

2

6

High-throughput

0.629

High

209196

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

6

High-throughput

0.628

High

209233

RUXE
Small nuclear ribonucleoprotein E

2

3

High-throughput

0.628

High

209243

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

8

High-throughput

0.628

High

209329

RBM42
RNA-binding protein 42

2

9

High-throughput

0.628

High

209352

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

18

High-throughput

0.628

High

209360

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

13

High-throughput

0.628

High

209154

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

16

Small-scale

0.621

High

209182

FINC
Fibronectin

1

5

High-throughput

0.618

High

209199

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.618

High

209201

ARBK1
Beta-adrenergic receptor kinase 1

1

7

High-throughput

0.618

High

209209

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

209212

LIFR
Leukemia inhibitory factor receptor

1

4

High-throughput

0.618

High

209216

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.618

High

209218

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.618

High

209223

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.618

High

209247

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.618

High

209325

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.618

High

209172

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.618

High

209232

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.618

High

209240

H4
Histone H4

1

7

High-throughput

0.618

High

209241

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.618

High

209245

H31
Histone H3.1

1

10

High-throughput

0.618

High

209251

ERCC6
DNA excision repair protein ERCC-6

1

20

Small-scale

0.618

High

209255

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

12

High-throughput

0.618

High

209257

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

15

High-throughput

0.618

High

209266

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

15

High-throughput

0.618

High

209340

ANLN
Anillin

1

7

High-throughput

0.618

High

209347

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

11

High-throughput

0.618

High

209177

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

3

High-throughput

0.611

High

209208

COIL
Coilin

2

1

High-throughput

0.611

High

209235

RUXG
Small nuclear ribonucleoprotein G

2

20

High-throughput

0.611

High

209265

RBM39
RNA-binding protein 39

2

12

High-throughput

0.611

High

209294

CATAC
Centrosomal AT-AC splicing factor

2

0

Small-scale

0.585

High

209161

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.584

High

209345

TMOD3
Tropomodulin-3

2

2

High-throughput

0.574

High

209315

GPKOW
G-patch domain and KOW motifs-containing protein

1

1

High-throughput

0.573

High

209187

LYN
Tyrosine-protein kinase Lyn

2

6

High-throughput

0.571

High

156715

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.553

High

209244

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.553

High

209289

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

209334

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

209337

RC3H2
Roquin-2

1

14

High-throughput

0.553

High

127744

IKBE
NF-kappa-B inhibitor epsilon

1

10

High-throughput

0.536

High

209162

NUAK1
NUAK family SNF1-like kinase 1

1

3

High-throughput

0.536

High

209164

CCNT1
Cyclin-T1

1

4

High-throughput

0.536

High

209167

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

4

High-throughput

0.536

High

209169

SF3B1
Splicing factor 3B subunit 1

1

8

High-throughput

0.536

High

209189

SNRPA
U1 small nuclear ribonucleoprotein A

1

9

High-throughput

0.536

High

209190

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

209194

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

209200

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.536

High

209203

U2AF2
Splicing factor U2AF 65 kDa subunit

1

19

High-throughput

0.536

High

209211

FRK
Tyrosine-protein kinase FRK

1

6

High-throughput

0.536

High

209213

MK08
Mitogen-activated protein kinase 8

1

6

High-throughput

0.536

High

209215

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.536

High

209222

CLK2
Dual specificity protein kinase CLK2

1

12

High-throughput

0.536

High

209229

PFD3
Prefoldin subunit 3

1

7

High-throughput

0.536

High

209236

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

15

High-throughput

0.536

High

209239

SMD3
Small nuclear ribonucleoprotein Sm D3

1

20

High-throughput

0.536

High

209246

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.536

High

209248

TXN4A
Thioredoxin-like protein 4A

1

2

High-throughput

0.536

High

209250

OTUD4
OTU domain-containing protein 4

1

3

High-throughput

0.536

High

209254

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

209262

CUL3
Cullin-3

1

20

High-throughput

0.536

High

209277

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

13

High-throughput

0.536

High

209285

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.536

High

209297

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

17

High-throughput

0.536

High

209307

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

2

High-throughput

0.536

High

209309

SYNE2
Nesprin-2

1

6

High-throughput

0.536

High

209314

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

209317

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.536

High

209322

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.536

High

209323

PFD5
Prefoldin subunit 5

1

9

High-throughput

0.536

High

209339

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.536

High

209349

KDM5B
Lysine-specific demethylase 5B

1

8

High-throughput

0.536

High

209354

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

209179

RPP29
Ribonuclease P protein subunit p29

1

0

High-throughput

0.513

High

209274

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

High-throughput

0.513

High

209324

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

209350

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.513

High

209252

SRSF1
Serine/arginine-rich splicing factor 1

1

15

Small-scale

0.501

High

209228

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

1

High-throughput

0.494

High

182059

PFD6
Prefoldin subunit 6

1

6

High-throughput

0.489

High

209166

PFD1
Prefoldin subunit 1

1

6

High-throughput

0.489

High

209253

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.489

High

209276

CDC37
Hsp90 co-chaperone Cdc37

1

2

High-throughput

0.489

High

209283

FKB15
FK506-binding protein 15

1

10

High-throughput

0.489

High

209288

SAS6
Spindle assembly abnormal protein 6 homolog

1

7

High-throughput

0.489

High

209302

ENAH
Protein enabled homolog

1

10

High-throughput

0.489

High

209305

CERK1
Ceramide kinase

1

1

High-throughput

0.489

High

209313

KIFA3
Kinesin-associated protein 3

1

18

High-throughput

0.489

High

209357

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

6

High-throughput

0.489

High

128634

MEN1
Menin

1

4

High-throughput

0.479

High

172284

XPO1
Exportin-1

1

16

High-throughput

0.479

High

209159

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

209163

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

209165

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

209175

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

209176

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

209181

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

209183

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

209188

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.479

High

209191

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

Small-scale

0.479

High

209192

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.479

High

209195

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.479

High

209198

CEBPB
CCAAT/enhancer-binding protein beta

1

15

High-throughput

0.479

High

209202

BRD2
Bromodomain-containing protein 2

1

16

High-throughput

0.479

High

209204

PML
Protein PML

1

16

High-throughput

0.479

High

209205

STIP1
Stress-induced-phosphoprotein 1

1

16

High-throughput

0.479

High

209206

ARRB2
Beta-arrestin-2

1

4

High-throughput

0.479

High

209210

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

209214

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

209217

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

209219

ARRB1
Beta-arrestin-1

1

4

High-throughput

0.479

High

209220

KC1E
Casein kinase I isoform epsilon

1

15

High-throughput

0.479

High

209225

MECP2
Methyl-CpG-binding protein 2

1

11

High-throughput

0.479

High

209226

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

209230

WDR5
WD repeat-containing protein 5

1

18

High-throughput

0.479

High

209259

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

209260

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

209264

ELOA1
Elongin-A

1

8

High-throughput

0.479

High

209270

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

209271

RNPS1
RNA-binding protein with serine-rich domain 1

1

14

High-throughput

0.479

High

209272

PCBP1
Poly(rC)-binding protein 1

1

13

High-throughput

0.479

High

209275

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

209280

LARP7
La-related protein 7

1

16

High-throughput

0.479

High

209286

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

209291

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

209292

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

209293

PATL1
Protein PAT1 homolog 1

1

2

High-throughput

0.479

High

209295

THOC4
THO complex subunit 4

1

7

High-throughput

0.479

High

209296

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.479

High

209298

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

209299

SLX4
Structure-specific endonuclease subunit SLX4

1

11

High-throughput

0.479

High

209303

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

209304

SNIP1
Smad nuclear-interacting protein 1

1

5

High-throughput

0.479

High

209306

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

209311

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

209316

TF3B
Transcription factor IIIB 90 kDa subunit

1

3

Small-scale

0.479

High

209326

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

209328

GCP2
Gamma-tubulin complex component 2

1

1

High-throughput

0.479

High

209332

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.479

High

209343

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

209346

AKA7G
A-kinase anchor protein 7 isoform gamma

1

1

High-throughput

0.479

High

209348

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

209355

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

209362

MAFB
Transcription factor MafB

1

12

High-throughput

0.479

High

209178

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.458

High

209197

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

209363

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

209185

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.457

High

71540

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

20

High-throughput

0.445

High

116753

I3L1H5
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

1

High-throughput

0.445

High

209186

JUN
Transcription factor Jun

1

18

High-throughput

0.445

High

209193

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.445

High

209207

BMI1
Polycomb complex protein BMI-1

1

19

High-throughput

0.445

High

209281

NCBP3
Nuclear cap-binding protein subunit 3

1

2

High-throughput

0.445

High

209160

PRIC3
Prickle planar cell polarity protein 3

1

8

High-throughput

0.437

High

209168

OBSL1
Obscurin-like protein 1

1

10

High-throughput

0.437

High

209173

RHBT1
Rho-related BTB domain-containing protein 1

1

17

High-throughput

0.437

High

209184

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.437

High

209256

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

10

High-throughput

0.437

High

209267

CUL7
Cullin-7

1

5

High-throughput

0.437

High

209278

FSCN1
Fascin

1

2

High-throughput

0.437

High

209279

KNOP1
Lysine-rich nucleolar protein 1

1

2

High-throughput

0.437

High

209301

PTGR2
Prostaglandin reductase 2

1

3

High-throughput

0.437

High

209310

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

High-throughput

0.437

High

209320

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

209327

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.437

High

209331

CP250
Centrosome-associated protein CEP250

1

15

High-throughput

0.437

High

209333

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

1

High-throughput

0.437

High

209344

OLA1
Obg-like ATPase 1

1

6

High-throughput

0.437

High

209353

HECD1
E3 ubiquitin-protein ligase HECTD1

1

12

High-throughput

0.437

High

209356

RL26L
Ribosomal protein uL24-like

1

3

High-throughput

0.437

High

209221

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.408

High

108066

G3V3Y1
15-oxoprostaglandin 13-reductase

1

2

High-throughput

0.407

High

114429

H0Y413
Prickle planar cell polarity protein 3

1

8

High-throughput

0.407

High

209158

AKA7A
A-kinase anchor protein 7 isoforms alpha and beta

1

1

High-throughput

0.407

High

209341

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

4

0

High-throughput

0.367

High

209242

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.249

Low

209284

SPOUT
28S rRNA

1

0

High-throughput

0.249

Low

209321

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.249

Low

209351

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.249

Low

209338

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025